Title : The HIV protease inhibitor nelfinavir downregulates Akt phosphorylation by inhibiting proteasomal activity and inducing the unfolded protein response.

Pub. Date : 2007 Apr

PMID : 17460771






3 Functional Relationships(s)
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1 The HIV protease inhibitor nelfinavir downregulates Akt phosphorylation by inhibiting proteasomal activity and inducing the unfolded protein response. Nelfinavir AKT serine/threonine kinase 1 Homo sapiens
2 Furthermore, our data indicate that nelfinavir decreases Akt phosphorylation by triggering this response. Nelfinavir AKT serine/threonine kinase 1 Homo sapiens
3 These findings may have important implications in understanding how nelfinavir may increase radiation sensitivity and also result in downregulation of the PI3K/Akt pathway. Nelfinavir AKT serine/threonine kinase 1 Homo sapiens