Pub. Date : 2005 Sep 15
PMID : 16166302
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Five first-generation HPIs were subsequently tested and three of the five (amprenavir, nelfinavir, and saquinavir but not ritonavir or indinavir) inhibited Akt phosphorylation at Ser473 at serum concentrations routinely achieved in HIV patients. | Nelfinavir | AKT serine/threonine kinase 1 | Homo sapiens |
| 2 | In addition, in vivo, doses of amprenavir or nelfinavir comparable with the therapeutic levels achieved in HIV patients were sufficient to down-regulate phosphorylation of Akt in SQ20B and T24 xenografts. | Nelfinavir | AKT serine/threonine kinase 1 | Homo sapiens |