2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one

AKT serine/threonine kinase 1 ; Homo sapiens







87 Article(s)
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51 19917268 Angiogenic activity of sesamin through the activation of multiple signal pathways. 2010 Jan 1 1
52 19956885 Imatinib mesylate (STI571) enhances amrubicin-induced cytotoxic activity through inhibition of the phosphatidylinositol 3-kinase/Akt pathway in small cell lung cancer cells. 2010 Jan 1
53 20008963 A polysaccharide, MDG-1, induces S1P1 and bFGF expression and augments survival and angiogenesis in the ischemic heart. 2010 Jan 2
54 20093382 TRPV2 channel negatively controls glioma cell proliferation and resistance to Fas-induced apoptosis in ERK-dependent manner. 2010 May 1
55 20336745 Type I collagen promotes proliferation and osteogenesis of human mesenchymal stem cells via activation of ERK and Akt pathways. 2010 Sep 1 1
56 20506505 Overexpression of fucosyltransferase IV promotes A431 cell proliferation through activating MAPK and PI3K/Akt signaling pathways. 2010 Nov 1
57 18996613 Osteopontin increases lung cancer cells migration via activation of the alphavbeta3 integrin/FAK/Akt and NF-kappaB-dependent pathway. 2009 Jun 1
58 19344769 Tetanus toxin H(C) fragment reduces neuronal MPP+ toxicity. 2009 Jul 1
59 18315925 Brain derived neurotrophic factor induces endothelial cells angiogenesis through AKT and ERK1/2 signal pathway. 2008 Feb 1
60 18341625 Mitogenic and anti-apoptotic actions of adipocyte-derived hormone leptin in prostate cancer cells. 2008 Aug 1
61 18691227 Down-regulation of the PI3-kinase/Akt pathway by ERK MAP kinase in growth factor signaling. 2008 Sep 1
62 17106060 Ghrelin has novel vascular actions that mimic PI 3-kinase-dependent actions of insulin to stimulate production of NO from endothelial cells. 2007 Mar 2
63 17161815 PD98059 triggers G1 arrest and apoptosis in human leukemic U937 cells through downregulation of Akt signal pathway. 2007 Jan 3
64 17350964 PI3K/Akt and ERK1/2 signalling pathways are involved in endometrial cell migration induced by 17beta-estradiol and growth factors. 2007 May 1
65 17388918 Combined targeting of MAPK and AKT signalling pathways is a promising strategy for melanoma treatment. 2007 Jun 1
66 17404034 Immune complexes induce monocyte survival through defined intracellular pathways. 2007 Jan 1
67 17539658 Tea polyphenol (-)-epigallocatechin 3-gallate suppresses heregulin-beta1-induced fatty acid synthase expression in human breast cancer cells by inhibiting phosphatidylinositol 3-kinase/Akt and mitogen-activated protein kinase cascade signaling. 2007 Jun 27 1
68 17950696 Hypoxia inhibits the SDF-1-dependent migration of human leukemic cell line HL-60 via blocking of Akt activation. 2007 Dec 14 1
69 16884765 Stromal cell-derived factor 1alpha stimulates human endometrial carcinoma cell growth through the activation of both extracellular signal-regulated kinase 1/2 and Akt. 2006 Dec 1
70 17052670 Key regulators in bee venom-induced apoptosis are Bcl-2 and caspase-3 in human leukemic U937 cells through downregulation of ERK and Akt. 2006 Dec 5 1
71 17068339 Dephosphorylation by default, a potential mechanism for regulation of insulin receptor substrate-1/2, Akt, and ERK1/2. 2006 Dec 22 1
72 15572039 Low proliferation and high apoptosis of osteoblastic cells on hydrophobic surface are associated with defective Ras signaling. 2005 Feb 1 1
73 15684417 Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) induces rheumatoid arthritis synovial fibroblast proliferation through mitogen-activated protein kinases and phosphatidylinositol 3-kinase/Akt. 2005 Apr 22 1
74 16100051 Cell-signaling evidence for adenosine stimulation of coronary smooth muscle proliferation via the A1 adenosine receptor. 2005 Sep 16 1
75 14694442 The molecular mechanism of sensitization to Fas-mediated apoptosis by 2-methoxyestradiol in PC3 prostate cancer cells. 2004 Jan 1
76 14985355 Stem cell factor/c-kit signaling promotes the survival, migration, and capillary tube formation of human umbilical vein endothelial cells. 2004 Apr 30 1
77 15319373 Leptin as a novel profibrogenic cytokine in hepatic stellate cells: mitogenesis and inhibition of apoptosis mediated by extracellular regulated kinase (Erk) and Akt phosphorylation. 2004 Oct 1
78 15389877 Molecular pathways involved in the anti-apoptotic effect of 1,25-dihydroxyvitamin D3 in primary human keratinocytes. 2004 Nov 15 1
79 14522909 Insulin-like growth factor-1 induces adhesion and migration in human multiple myeloma cells via activation of beta1-integrin and phosphatidylinositol 3'-kinase/AKT signaling. 2003 Sep 15 1
80 11902114 Phosphatidylinositol 3-kinase is a central mediator of NMDA receptor signalling to MAP kinase (Erk1/2), Akt/PKB and CREB in striatal neurones. 2002 Jan 1
81 12032842 Insulin restores differentiation of Ras-transformed C2C12 myoblasts by inducing NF-kappaB through an AKT/P70S6K/p38-MAPK pathway. 2002 May 23 1
82 12034359 Delayed ERK activation by ceramide reduces melanin synthesis in human melanocytes. 2002 Sep 1
83 12051724 Estrogen regulation of c-fos gene expression through phosphatidylinositol-3-kinase-dependent activation of serum response factor in MCF-7 breast cancer cells. 2002 Jun 7 1
84 12411472 Leptin induces endothelial cell migration through Akt, which is inhibited by PPARgamma-ligands. 2002 Nov 2
85 11454948 Activation of Akt1 by human 5-hydroxytryptamine (serotonin)1B receptors is sensitive to inhibitors of MEK. 2001 Aug 3
86 10873605 IGF-1 regulates cardiac fibroblast apoptosis induced by osmotic stress. 2000 Jun 24 1
87 11228049 Insulin-like growth factor-I-dependent signal transduction pathways leading to the induction of cell growth and differentiation of human neuroblastoma cell line SH-SY5Y: the roles of MAP kinase pathway and PI 3-kinase pathway. 2000 Dec 1