Title : Activation of Akt1 by human 5-hydroxytryptamine (serotonin)1B receptors is sensitive to inhibitors of MEK.

Pub. Date : 2001 Aug

PMID : 11454948






3 Functional Relationships(s)
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1 In the present study, we examined the effects of PD098059 and U0126, two structurally dissimilar inhibitors of MAP kinase kinase (MEK1/2), on the activation of ERK and Akt stimulated by human 5-hydroxytryptamine(1B) (serotonin) (5-HT1B) receptors. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one AKT serine/threonine kinase 1 Homo sapiens
2 Nevertheless, our findings that PD098059 and U0126 inhibit activation of Akt at commonly used concentrations demonstrate that in at least some systems, these compounds inhibit activation of both ERK and Akt, and cannot be used to discern the relative roles of each pathway in mediating cellular responses. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one AKT serine/threonine kinase 1 Homo sapiens
3 Nevertheless, our findings that PD098059 and U0126 inhibit activation of Akt at commonly used concentrations demonstrate that in at least some systems, these compounds inhibit activation of both ERK and Akt, and cannot be used to discern the relative roles of each pathway in mediating cellular responses. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one AKT serine/threonine kinase 1 Homo sapiens