Pub. Date : 2007 Jan
PMID : 17161815
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | PD98059 triggers G1 arrest and apoptosis in human leukemic U937 cells through downregulation of Akt signal pathway. | 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one | AKT serine/threonine kinase 1 | Homo sapiens |
| 2 | Moreover, PD98059 down-regulated Akt phosphorylation and produced a synergy effect of apoptosis with LY294002 co-treatment. | 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one | AKT serine/threonine kinase 1 | Homo sapiens |
| 3 | Thus, our results imply that PD98059-induced apoptosis is significantly involved in down-regulation of Bcl-2, caspase-3 activity, the Akt pathway, and some of the biological functions in U937 cells. | 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one | AKT serine/threonine kinase 1 | Homo sapiens |