ursolic acid

AKT serine/threonine kinase 1 ; Homo sapiens







41 Article(s)
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1 33549076 Ursolic acid induces apoptosis and anoikis in colorectal carcinoma RKO cells. 2021 Feb 6 1
2 34512368 Targeting Autophagy with Natural Compounds in Cancer: A Renewed Perspective from Molecular Mechanisms to Targeted Therapy. 2021 1
3 34768915 Ursolic Acid Accelerates Paclitaxel-Induced Cell Death in Esophageal Cancer Cells by Suppressing Akt/FOXM1 Signaling Cascade. 2021 Oct 25 3
4 31981747 Prediction of the mechanisms of Xiaoai Jiedu Recipe in the treatment of breast cancer: A comprehensive approach study with experimental validation. 2020 Apr 24 1
5 32521863 Anticancer activity of ursolic acid on human ovarian cancer cells via ROS and MMP mediated apoptosis, cell cycle arrest and downregulation of PI3K/AKT pathway. 2020 Mar-Apr 2
6 33321911 Reactive Oxygen Species-Mediated Autophagy by Ursolic Acid Inhibits Growth and Metastasis of Esophageal Cancer Cells. 2020 Dec 10 2
7 30538052 Fluorescent labeling of ursolic acid with FITC for investigation of its cytotoxic activity using confocal microscopy. 2019 Jun 1
8 31062913 Ursolic acid induces apoptosis and autophagy in oral cancer cells. 2019 Sep 1
9 31151763 Inhibitory effects of ursolic acid from Bushen Yijing Formula on TGF-β1-induced human umbilical vein endothelial cell fibrosis via AKT/mTOR signaling and Snail gene. 2019 May 3
10 31423212 Ursolic acid isolated from Isodon excisoides induces apoptosis and inhibits invasion of GBC-SD gallbladder carcinoma cells. 2019 Aug 1
11 31547522 Ursolic and Oleanolic Acids Induce Mitophagy in A549 Human Lung Cancer Cells. 2019 Sep 23 1
12 29428962 Ursolic Acid Attenuates High Glucose-Mediated Mesangial Cell Injury by Inhibiting the Phosphatidylinositol 3-Kinase/Akt/Mammalian Target of Rapamycin (PI3K/Akt/mTOR) Signaling Pathway. 2018 Feb 11 3
13 29956797 Ursolic acid elicits intrinsic apoptotic machinery by downregulating the phosphorylation of AKT/BAD signaling in human cisplatin‑resistant oral cancer CAR cells. 2018 Sep 2
14 30104508 Ursolic Acid-Induced Apoptosis via Regulation of the PI3K/Akt and MAPK Signaling Pathways in Huh-7 Cells. 2018 Aug 13 2
15 28213701 Ursolic acid-mediated changes in glycolytic pathway promote cytotoxic autophagy and apoptosis in phenotypically different breast cancer cells. 2017 Jun 1
16 29042957 Ursolic acid inhibits breast cancer growth by inhibiting proliferation, inducing autophagy and apoptosis, and suppressing inflammatory responses via the PI3K/AKT and NF-κB signaling pathways in vitro. 2017 Oct 2
17 27104510 The Apoptotic Effect of Ursolic Acid on SK-Hep-1 Cells is Regulated by the PI3K/Akt, p38 and JNK MAPK Signaling Pathways. 2016 Apr 20 2
18 27219337 Down-Regulation of AKT Signalling by Ursolic Acid Induces Intrinsic Apoptosis and Sensitization to Doxorubicin in Soft Tissue Sarcoma. 2016 4
19 27221674 Ursolic acid inhibits proliferation and reverses drug resistance of ovarian cancer stem cells by downregulating ABCG2 through suppressing the expression of hypoxia-inducible factor-1α in vitro. 2016 Jul 1
20 27262506 Resistance to ursolic acid-induced apoptosis through involvement of melanogenesis and COX-2/PGE2 pathways in human M4Beu melanoma cancer cells. 2016 Jul 1 1
21 27331824 l-Leucine Increases Skeletal Muscle IGF-1 but Does Not Differentially Increase Akt/mTORC1 Signaling and Serum IGF-1 Compared to Ursolic Acid in Response to Resistance Exercise in Resistance-Trained Men. 2016 Sep-Oct 1
22 27634378 Ursolic acid-mediated apoptosis of K562 cells involves Stat5/Akt pathway inhibition through the induction of Gfi-1. 2016 Sep 16 4
23 25689721 Ursolic acid attenuates diabetic mesangial cell injury through the up-regulation of autophagy via miRNA-21/PTEN/Akt/mTOR suppression. 2015 1
24 26347199 A bioinformatic and mechanistic study elicits the antifibrotic effect of ursolic acid through the attenuation of oxidative stress with the involvement of ERK, PI3K/Akt, and p38 MAPK signaling pathways in human hepatic stellate cells and rat liver. 2015 1
25 26503559 Ursolic Acid Induces Apoptosis of Prostate Cancer Cells via the PI3K/Akt/mTOR Pathway. 2015 4
26 24484591 Ursolic acid induces U937 cells differentiation by PI3K/Akt pathway activation. 2014 Jan 4
27 24740400 Ursolic acid inhibits leucine-stimulated mTORC1 signaling by suppressing mTOR localization to lysosome. 2014 1
28 25329874 Ursolic acid increases glucose uptake through the PI3K signaling pathway in adipocytes. 2014 1
29 22549898 Suppression of AMF/PGI-mediated tumorigenic activities by ursolic acid in cultured hepatoma cells and in a mouse model. 2013 Oct 1
30 23325562 Activation of AMP-activated protein kinase and phosphorylation of glycogen synthase kinase3 β mediate ursolic acid induced apoptosis in HepG2 liver cancer cells. 2013 Nov 2
31 23483134 Ursolic acid induces apoptosis via Akt/NF-κB signaling suppression in T24 human bladder cancer cells. 2013 May 3
32 23737956 Ursolic acid simultaneously targets multiple signaling pathways to suppress proliferation and induce apoptosis in colon cancer cells. 2013 3
33 22178132 Autophagy inhibition enhances ursolic acid-induced apoptosis in PC3 cells. 2012 Feb 1
34 22477202 Ursolic acid-induced apoptosis in K562 cells involving upregulation of PTEN gene expression and inactivation of the PI3K/Akt pathway. 2012 Mar 3
35 22641480 Ursolic acid inhibits growth and induces apoptosis in gemcitabine-resistant human pancreatic cancer via the JNK and PI3K/Akt/NF-κB pathways. 2012 Aug 1
36 20137120 [Apoptosis of jurkat cells induced by ursolic acid and its mechanism]. 2010 Feb 1
37 20146252 Ursolic acid induces PC-3 cell apoptosis via activation of JNK and inhibition of Akt pathways in vitro. 2010 Apr 3
38 20352621 Ursolic acid, a naturally occurring triterpenoid, suppresses migration and invasion of human breast cancer cells by modulating c-Jun N-terminal kinase, Akt and mammalian target of rapamycin signaling. 2010 Sep 3
39 19174695 Downregulation of survivin and activation of caspase-3 through the PI3K/Akt pathway in ursolic acid-induced HepG2 cell apoptosis. 2009 Apr 5
40 18448068 Modulation of angiogenic factors by ursolic acid. 2008 Jul 4 3
41 17213663 Regulation of the phosphatidylinositol 3-kinase-Akt and the mitogen-activated protein kinase pathways by ursolic acid in human endometrial cancer cells. 2007 Jan 2