Pub. Date : 2016
PMID : 27219337
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Down-Regulation of AKT Signalling by Ursolic Acid Induces Intrinsic Apoptosis and Sensitization to Doxorubicin in Soft Tissue Sarcoma. | ursolic acid | AKT serine/threonine kinase 1 | Homo sapiens |
| 2 | UA treatment (6-9 h) strongly blocked the survival AKT/GSK3beta/beta-catenin signalling pathway, which led to a concomitant reduction of the anti-apoptotic proteins c-Myc and p21, altogether resulting in the activation of intrinsic apoptosis. | ursolic acid | AKT serine/threonine kinase 1 | Homo sapiens |
| 3 | Interestingly, UA at low concentrations (10-15 muM) enhanced the antitumoral effects of DXR by up to 2-fold, while in parallel inhibiting DXR-induced AKT activation and p21 expression, two proteins implicated in antitumoral drug resistance and cell survival. | ursolic acid | AKT serine/threonine kinase 1 | Homo sapiens |
| 4 | In conclusion, UA is able to induce intrinsic apoptosis in human STS cells and also to sensitize these cells to DXR by blocking the AKT signalling pathway. | ursolic acid | AKT serine/threonine kinase 1 | Homo sapiens |