Pub. Date : 2014 Jan
PMID : 24484591
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Ursolic acid induces U937 cells differentiation by PI3K/Akt pathway activation. | ursolic acid | AKT serine/threonine kinase 1 | Homo sapiens |
| 2 | RESULTS: It was found that UA could induce the differentiation of U937cells and Akt-activity was significantly increased during differentiation. | ursolic acid | AKT serine/threonine kinase 1 | Homo sapiens |
| 3 | Additionally, LY294002, a PI3K-Akt inhibitor, could block the differentiation of U937 cells induced by UA. | ursolic acid | AKT serine/threonine kinase 1 | Homo sapiens |
| 4 | CONCLUSION: UA could induce the differentiation of U937 cells by activating the PI3K/Akt pathway, and it could be a potential candidate as a differentiation-inducing agent for the therapy of leukemia. | ursolic acid | AKT serine/threonine kinase 1 | Homo sapiens |