Pub. Date : 2012 Mar
PMID : 22477202
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Ursolic acid-induced apoptosis in K562 cells involving upregulation of PTEN gene expression and inactivation of the PI3K/Akt pathway. | ursolic acid | AKT serine/threonine kinase 1 | Homo sapiens |
| 2 | Here, we demonstrated that UA was able to inhibit growth, induce apoptosis in a human chronic myelogenous leukemia cell line (K562 cells) via upregulation of PTEN gene expression, inhibit Akt kinase activity, change mitochondrial transmembrane potential and reduce the release of cytochrome c and the activity of caspases. | ursolic acid | AKT serine/threonine kinase 1 | Homo sapiens |
| 3 | These results suggest that UA may elicit its strong antitumor effects via upregulation of the PTEN gene and inhibition of the PI3K/Akt pathway. | ursolic acid | AKT serine/threonine kinase 1 | Homo sapiens |