Lapatinib

AKT serine/threonine kinase 1 ; Homo sapiens







80 Article(s)
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51 24112719 Heregulin induces resistance to lapatinib-mediated growth inhibition of HER2-amplified cancer cells. 2013 Dec 1
52 24263233 Phosphoproteomic analysis identifies activated MET-axis PI3K/AKT and MAPK/ERK in lapatinib-resistant cancer cell line. 2013 Nov 22 1
53 22043997 Pharmacologic inhibition of mTOR improves lapatinib sensitivity in HER2-overexpressing breast cancer cells with primary trastuzumab resistance. 2012 Feb 1
54 22238368 MET activation mediates resistance to lapatinib inhibition of HER2-amplified gastric cancer cells. 2012 Mar 1
55 22293713 Lapatinib, a dual inhibitor of EGFR and HER2, has synergistic effects with 5-fluorouracil on esophageal carcinoma. 2012 May 1
56 22407832 Dual mTORC1/2 and HER2 blockade results in antitumor activity in preclinical models of breast cancer resistant to anti-HER2 therapy. 2012 May 1 2
57 22686613 Overcoming treatment resistance in HER2-positive breast cancer: potential strategies. 2012 Jun 18 1
58 22745588 Activation of multiple ERBB family receptors mediates glioblastoma cancer stem-like cell resistance to EGFR-targeted inhibition. 2012 May 1
59 22815900 Loss of activating EGFR mutant gene contributes to acquired resistance to EGFR tyrosine kinase inhibitors in lung cancer cells. 2012 1
60 22892392 BCAR4 induces antioestrogen resistance but sensitises breast cancer to lapatinib. 2012 Sep 4 1
61 21252284 Synergistic effects of foretinib with HER-targeted agents in MET and HER1- or HER2-coactivated tumor cells. 2011 Mar 1
62 21385943 Transcriptional and posttranslational up-regulation of HER3 (ErbB3) compensates for inhibition of the HER2 tyrosine kinase. 2011 Mar 22 1
63 21464044 The dual EGFR/HER2 inhibitor lapatinib synergistically enhances the antitumor activity of the histone deacetylase inhibitor panobinostat in colorectal cancer models. 2011 May 15 1
64 20103665 Radiosensitization of epidermal growth factor receptor/HER2-positive pancreatic cancer is mediated by inhibition of Akt independent of ras mutational status. 2010 Feb 1 1
65 20126311 Grb7 upregulation is a molecular adaptation to HER2 signaling inhibition due to removal of Akt-mediated gene repression. 2010 Feb 2 1
66 20179222 Lapatinib, a dual EGFR and HER2 kinase inhibitor, selectively inhibits HER2-amplified human gastric cancer cells and is synergistic with trastuzumab in vitro and in vivo. 2010 Mar 1 2
67 20457354 Lapatinib in combination with radiation diminishes tumor regrowth in HER2+ and basal-like/EGFR+ breast tumor xenografts. 2010 Jun 1 2
68 20501798 Activated phosphoinositide 3-kinase/AKT signaling confers resistance to trastuzumab but not lapatinib. 2010 Jun 2
69 20511180 ErbB/HER receptor activation and preclinical efficacy of lapatinib in vestibular schwannoma. 2010 Aug 1
70 20855960 Inhibition of MCL-1 in breast cancer cells promotes cell death in vitro and in vivo. 2010 Nov 1 1
71 19287975 Lapatinib, a dual inhibitor of ErbB-1/-2 receptors, enhances effects of combination chemotherapy in bladder cancer cells. 2009 Apr 1
72 18544666 Lapatinib resistance in HCT116 cells is mediated by elevated MCL-1 expression and decreased BAK activation and not by ERBB receptor kinase mutation. 2008 Sep 1
73 18980964 Acquired resistance to small molecule ErbB2 tyrosine kinase inhibitors. 2008 Nov 1 1
74 17308062 Lapatinib induces apoptosis in trastuzumab-resistant breast cancer cells: effects on insulin-like growth factor I signaling. 2007 Feb 2
75 17513611 Delineation of molecular mechanisms of sensitivity to lapatinib in breast cancer cell lines using global gene expression profiles. 2007 May 6
76 16397255 Blockade of EGFR and ErbB2 by the novel dual EGFR and ErbB2 tyrosine kinase inhibitor GW572016 sensitizes human colon carcinoma GEO cells to apoptosis. 2006 Jan 1 1
77 16452222 Activity of the dual kinase inhibitor lapatinib (GW572016) against HER-2-overexpressing and trastuzumab-treated breast cancer cells. 2006 Feb 1 1
78 14737100 Truncated ErbB2 receptor (p95ErbB2) is regulated by heregulin through heterodimer formation with ErbB3 yet remains sensitive to the dual EGFR/ErbB2 kinase inhibitor GW572016. 2004 Jan 22 2
79 14751502 Effects of the EGFR/HER2 kinase inhibitor GW572016 on EGFR- and HER2-overexpressing breast cancer cell line proliferation, radiosensitization, and resistance. 2004 Feb 1 1
80 12214266 Anti-tumor activity of GW572016: a dual tyrosine kinase inhibitor blocks EGF activation of EGFR/erbB2 and downstream Erk1/2 and AKT pathways. 2002 Sep 12 5