Pub. Date : 2010 Jun
PMID : 20501798
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | In these cells, trastuzumab had little effect on AKT phosphorylation, whereas lapatinib retained activity through the dephosphorylation of AKT. | Lapatinib | AKT serine/threonine kinase 1 | Homo sapiens |
| 2 | Thus, increased activation of the PI3K/AKT pathway correlates with resistance to trastuzumab, which can be overcome by lapatinib. | Lapatinib | AKT serine/threonine kinase 1 | Homo sapiens |