Genistein

AKT serine/threonine kinase 1 ; Homo sapiens







88 Article(s)
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51 19406242 Evidence that low-dose, long-term genistein treatment inhibits oestradiol-stimulated growth in MCF-7 cells by down-regulation of the PI3-kinase/Akt signalling pathway. 2009 Aug 1
52 19723095 Genistein inhibits cell growth by modulating various mitogen-activated protein kinases and AKT in cervical cancer cells. 2009 Aug 4
53 19732843 Genistein induces G2/M cell cycle arrest and apoptosis of human ovarian cancer cells via activation of DNA damage checkpoint pathways. 2009 Dec 1
54 19909554 A combination of indol-3-carbinol and genistein synergistically induces apoptosis in human colon cancer HT-29 cells by inhibiting Akt phosphorylation and progression of autophagy. 2009 Nov 12 1
55 17961125 Involvement of phosphoinositide 3-kinase and Akt in the induction of muscle protein degradation by proteolysis-inducing factor. 2008 Feb 1 1
56 18431742 Genistein mediated histone acetylation and demethylation activates tumor suppressor genes in prostate cancer cells. 2008 Aug 1 1
57 18492603 Multi-targeted therapy of cancer by genistein. 2008 Oct 8 1
58 18687691 Regulation of Akt/FOXO3a/GSK-3beta/AR signaling network by isoflavone in prostate cancer cells. 2008 Oct 10 1
59 17131310 In vitro and in vivo molecular evidence of genistein action in augmenting the efficacy of cisplatin in pancreatic cancer. 2007 Feb 15 1
60 17234261 Genistein-induced apoptosis and autophagocytosis in ovarian cancer cells. 2007 Apr 2
61 17947488 Combination treatment of prostate cancer cell lines with bioactive soy isoflavones and perifosine causes increased growth arrest and/or apoptosis. 2007 Oct 15 1
62 16489011 Genistein represses telomerase activity via both transcriptional and posttranslational mechanisms in human prostate cancer cells. 2006 Feb 15 2
63 16585150 Using chemopreventive agents to enhance the efficacy of cancer therapy. 2006 Apr 1 1
64 16613577 The role of genistein and synthetic derivatives of isoflavone in cancer prevention and therapy. 2006 Apr 1
65 16899133 "Nutritional and chemopreventive anti-cancer agents up-regulate expression of p27Kip1, a cyclin-dependent kinase inhibitor, in mouse JB6 epidermal and human MCF7, MDA-MB-321 and AU565 breast cancer cells". 2006 Aug 9 1
66 17079479 Potentiation of the effect of erlotinib by genistein in pancreatic cancer: the role of Akt and nuclear factor-kappaB. 2006 Nov 1 1
67 15533642 Aging: gene silencing or gene activation? 2005 1
68 15883821 Genistein-induced apoptosis via Akt signaling pathway in anaplastic large-cell lymphoma. 2005 Sep 1
69 15946254 Lipoteichoic acid induces nuclear factor-kappaB activation and nitric oxide synthase expression via phosphatidylinositol 3-kinase, Akt, and p38 MAPK in RAW 264.7 macrophages. 2005 Jul 1
70 16083949 Potentiation of the radiation effect with genistein in cervical cancer cells. 2005 Oct 1
71 16204081 Molecular evidence for increased antitumor activity of gemcitabine by genistein in vitro and in vivo using an orthotopic model of pancreatic cancer. 2005 Oct 1 1
72 16379552 Genistein inhibits insulin-like growth factor-I receptor signaling in HT-29 human colon cancer cells: a possible mechanism of the growth inhibitory effect of Genistein. 2005 Winter 1
73 12554767 Estradiol rapidly activates Akt via the ErbB2 signaling pathway. 2003 May 1
74 12687010 Heregulin-beta1 regulates the estrogen receptor-alpha gene expression and activity via the ErbB2/PI 3-K/Akt pathway. 2003 Apr 10 1
75 12792805 Pleotropic effects of genistein on MCF-7 breast cancer cells. 2003 Jul 1
76 12879015 Inactivation of NF-kappaB by genistein is mediated via Akt signaling pathway in breast cancer cells. 2003 Jul 24 4
77 14628433 Soy isoflavones and cancer prevention. 2003 1
78 15686114 Genistein, a soy isoflavone, enhances necrotic-like cell death in a breast cancer cell treated with a chemotherapeutic agent. 2003 2
79 11795876 Copper ions strongly activate the phosphoinositide-3-kinase/Akt pathway independent of the generation of reactive oxygen species. 2002 Jan 15 1
80 12114442 Inhibition of nuclear factor kappaB activation in PC3 cells by genistein is mediated via Akt signaling pathway. 2002 Jul 7
81 12150980 Regulation of Akt by EGF-R inhibitors, a possible mechanism of EGF-R inhibitor-enhanced TRAIL-induced apoptosis. 2002 Jul 12 2
82 12495471 Differential mechanisms of constitutive Akt/PKB activation and its influence on gene expression in pancreatic cancer cells. 2002 Dec 1
83 12549765 Mechanisms of cancer chemoprevention by soy isoflavone genistein. 2002 1
84 11316564 Genistein, a tyrosine kinase inhibitor, enhanced radiosensitivity in human esophageal cancer cell lines in vitro: possible involvement of inhibition of survival signal transduction pathways. 2001 May 1 1
85 11375271 Myocardial Akt activation and gender: increased nuclear activity in females versus males. 2001 May 25 2
86 11751518 Genistein elicits pleiotropic molecular effects on head and neck cancer cells. 2001 Dec 1
87 10764736 The small G-protein Rac mediates depolarization-induced superoxide formation in human endothelial cells. 2000 Jun 23 1
88 10362672 Activation of Akt/protein kinase B after stimulation with angiotensin II in vascular smooth muscle cells. 1999 Jun 2