Title : Genistein represses telomerase activity via both transcriptional and posttranslational mechanisms in human prostate cancer cells.

Pub. Date : 2006 Feb 15

PMID : 16489011






2 Functional Relationships(s)
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1 Interestingly, we observed that genistein down-regulates the activation of Akt thereby phosphorylation of hTERT and inhibits its translocation to the nucleus. Genistein AKT serine/threonine kinase 1 Homo sapiens
2 These results show for the first time that genistein represses telomerase activity in prostate cancer cells not only by repressing hTERT transcriptional activity via c-Myc but also by posttranslational modification of hTERT via Akt. Genistein AKT serine/threonine kinase 1 Homo sapiens