Title : Differential mechanisms of constitutive Akt/PKB activation and its influence on gene expression in pancreatic cancer cells.

Pub. Date : 2002 Dec

PMID : 12495471






1 Functional Relationships(s)
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1 Phosphorylation of Akt was inhibited by the phosphatidylinositol-3-kinase (PI3K) inhibitor LY294002 and the tyrosine kinase inhibitor genistein in KMP-3 and KMP-4 cells, indicating that upstream signals are required for Akt activation in these two cell lines. Genistein AKT serine/threonine kinase 1 Homo sapiens