2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one

tumor necrosis factor ; Rattus norvegicus







44 Article(s)
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1 35465093 Red Nucleus Interleukin-6 Evokes Tactile Allodynia in Male Rats Through Modulating Spinal Pro-inflammatory and Anti-inflammatory Cytokines. 2022 1
2 32380573 Red nucleus IL-6 mediates the maintenance of neuropathic pain by inducing the productions of TNF-α and IL-1β through the JAK2/STAT3 and ERK signaling pathways. 2020 Aug 1
3 28662519 Neuroprotective Effects of Pycnogenol Against Oxygen-Glucose Deprivation/Reoxygenation-Induced Injury in Primary Rat Astrocytes via NF-κB and ERK1/2 MAPK Pathways. 2017 1
4 26505752 CCAAT/enhancer binding protein β regulates the expression of tumor necrosis factor-α in the nucleus pulposus cells. 2016 May 1
5 27382351 Cryptotanshinone inhibits TNF-α-induced LOX-1 expression by suppressing reactive oxygen species (ROS) formation in endothelial cells. 2016 Jul 1
6 27784654 Calcitonin Gene-Related Peptide Rescues Proximity Associations of Its Receptor Components, Calcitonin Receptor-Like Receptor and Receptor Activity-Modifying Protein 1, in Rat Uterine Artery Smooth Muscle Cells Exposed to Tumor Necrosis Factor Alpha. 2016 Dec 1
7 25338292 Repetitive ischemic preconditioning attenuates inflammatory reaction and brain damage after focal cerebral ischemia in rats: involvement of PI3K/Akt and ERK1/2 signaling pathway. 2015 Apr 1
8 26047595 TNF-α-mediated suppression of Leydig cell steroidogenesis involves DAX-1. 2015 Jul 1
9 26075533 TGF-β1 antagonizes TNF-α induced up-regulation of matrix metalloproteinase 3 in nucleus pulposus cells: role of the ERK1/2 pathway. 2015 Nov 1
10 24802761 Tumor necrosis factor-α regulates matrix metalloproteinase-2 expression and cell migration via ERK pathway in rat glomerular mesangial cells. 2014 Sep 2
11 23645013 Curcumin inhibits LPS-induced inflammation in rat vascular smooth muscle cells in vitro via ROS-relative TLR4-MAPK/NF-κB pathways. 2013 Jul 1
12 24161765 NF-κB, ERK, p38 MAPK and JNK contribute to the initiation and/or maintenance of mechanical allodynia induced by tumor necrosis factor-alpha in the red nucleus. 2013 Oct 3
13 22528462 Mitogen-activated protein kinase pathways are involved in the upregulation of calcitonin gene-related peptide of rat trigeminal ganglion after organ culture. 2012 Sep 1
14 22538404 Arachidonic acid stimulates TNFα production in Kupffer cells via a reactive oxygen species-pERK1/2-Egr1-dependent mechanism. 2012 Jul 15 1
15 21371423 Megalin is downregulated via LPS-TNF-α-ERK1/2 signaling pathway in proximal tubule cells. 2011 Apr 1 1
16 21481306 [Gentiana veitchiorum particles inhibited LPS induced pulmonary alveolar macrophages (AM) TNF-α production and the underlying mechanism]. 2011 Apr 3
17 20175209 Mitogen-activated protein kinases support survival of activated microglia that mediate thrombin-induced striatal injury in organotypic slice culture. 2010 Aug 1 1
18 20367970 [Myocardial inflammation and injury induced by coronary microembolization in rats: role of ERK1/2 signaling pathway]. 2010 Mar 2 1
19 19100731 Tumor necrosis factor (TNF) receptor-2-mediated DNA synthesis and proliferation in primary cultures of adult rat hepatocytes: The involvement of endogenous transforming growth factor-alpha. 2009 Feb 14 1
20 19181934 IL-10 attenuates TNF-alpha-induced NF kappaB pathway activation and cardiomyocyte apoptosis. 2009 Apr 1 1
21 16946004 Tumor necrosis factor-alpha activates transcription of inducible repressor form of 3',5'-cyclic adenosine 5'-monophosphate-responsive element binding modulator and represses P450 aromatase and inhibin alpha-subunit expression in rat ovarian granulosa cells by a p44/42 mitogen-activated protein kinase-dependent mechanism. 2006 Dec 1
22 15641147 Experimental study on the role of endotoxin in the development of hepatopulmonary syndrome. 2005 Jan 28 1
23 14764603 Tumor necrosis factor alpha produces insulin resistance in skeletal muscle by activation of inhibitor kappaB kinase in a p38 MAPK-dependent manner. 2004 Apr 23 1
24 14871416 PPARgamma ligands attenuate mesangial contractile dysfunction in high glucose. 2004 Mar 1
25 14978197 Dual regulation of tumor necrosis factor-alpha-induced CCL2/monocyte chemoattractant protein-1 expression in vascular smooth muscle cells by nuclear factor-kappaB and activator protein-1: modulation by type III phosphodiesterase inhibition. 2004 Jun 1
26 15196247 Differential regulation of mast cell cytokines by both dexamethasone and the p38 mitogen-activated protein kinase (MAPK) inhibitor SB203580. 2004 Jul 1
27 15365619 Rosiglitazone ameliorates insulin resistance in brown adipocytes of Wistar rats by impairing TNF-alpha induction of p38 and p42/p44 mitogen-activated protein kinases. 2004 Sep 1
28 12485415 Corticotropin-releasing hormone induces proliferation and TNF-alpha release in cultured rat microglia via MAP kinase signalling pathways. 2003 Jan 1
29 12608646 Suppression of tumor necrosis factor-alpha by beta2-adrenoceptor activation: role of mitogen-activated protein kinases in renal mesangial cells. 2003 Jan 1
30 12934647 Sodium salicylate inhibits expression of COX-2 through suppression of ERK and subsequent NF-kappaB activation in rat ventricular cardiomyocytes. 2003 Jul 1
31 11997699 Thrombin induces IL-10 production in microglia as a negative feedback regulator of TNF-alpha release. 2002 May 7 1
32 12028827 Role of mitogen-activated protein kinase activation in the production of inflammatory mediators: differences between primary rat alveolar macrophages and macrophage cell lines. 2002 May 24 2
33 12383959 Adenovirus infection induces microglial activation: involvement of mitogen-activated protein kinase pathways. 2002 Sep 6 1
34 12445823 Dilinoleoylphosphatidylcholine decreases acetaldehyde-induced TNF-alpha generation in Kupffer cells of ethanol-fed rats. 2002 Dec 6 1
35 11277995 TNF-alpha inhibits UCP-1 expression in brown adipocytes via ERKs. Opposite effect of p38MAPK. 2001 Mar 23 1
36 11689211 TNFalpha induces expression of transcription factors c-fos, Egr-1, and Ets-1 in vascular lesions through extracellular signal-regulated kinases 1/2. 2001 Nov 1
37 10880840 Association of decreased phosphorylation of ERK-2 with costimulation of rat T cell activation by MEK-1 inhibitors and TGF-beta1. 2000 Jun 1 2
38 10936177 Extracellular ATP triggers tumor necrosis factor-alpha release from rat microglia. 2000 Sep 1
39 11069065 Mitogen-activated protein kinase activity is involved in effector functions triggered by the CD94/NKG2-C NK receptor specific for HLA-E. 2000 Oct 1
40 11131279 Cytokine-activated p42/p44 MAP kinase is involved in inducible nitric oxide synthase gene expression independent from NF-kappaB activation in vascular smooth muscle cells. 2000 Nov 1
41 9931102 TNF-alpha-induced migration of vascular smooth muscle cells is MAPK dependent. 1999 Jan 3
42 10516205 TNF-alpha enhances cardiac myocyte NO production through MAP kinase-mediated NF-kappaB activation. 1999 Oct 2
43 9439626 Tyrosine kinase and MAPK inhibition of TNF-alpha- and EGF-stimulated IEC-6 cell growth. 1998 Jan 6 1
44 9579682 Mitogen-activated protein kinases activated by lipopolysaccharide and beta-amyloid in cultured rat microglia. 1998 Mar 30 1