Title : Tumor necrosis factor-α regulates matrix metalloproteinase-2 expression and cell migration via ERK pathway in rat glomerular mesangial cells.

Pub. Date : 2014 Sep

PMID : 24802761






2 Functional Relationships(s)
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1 PD98059 or NF-kappaB signal pathway selective inhibitor Bay 11-7082 effectively blocked TNF-alpha-induced expression of MMP-2 in rat MCs, as determined by gene and protein expression. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one tumor necrosis factor Rattus norvegicus
2 Furthermore, TNF-alpha could induce the cell migration of rat MCs, whereas ERK signal pathway specific inhibitor PD98059 compromised the cell migration triggered by TNF-alpha. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one tumor necrosis factor Rattus norvegicus