Title : NF-κB, ERK, p38 MAPK and JNK contribute to the initiation and/or maintenance of mechanical allodynia induced by tumor necrosis factor-alpha in the red nucleus.

Pub. Date : 2013 Oct

PMID : 24161765






3 Functional Relationships(s)
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1 Pre-treatment with NF-kappaB inhibitor PDTC, ERK inhibitor PD98059 or p38 MAPK inhibitor SB203580 at 30 min before TNF-alpha microinjected into the RN completely prevented TNF-alpha-evoked mechanical allodynia. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one tumor necrosis factor Rattus norvegicus
2 Post-treatment with PDTC, PD98059 or SP600125 (but not SB203580) at 4h after TNF-alpha microinjected into the RN significantly reversed TNF-alpha-evoked mechanical allodynia. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one tumor necrosis factor Rattus norvegicus
3 Post-treatment with PDTC, PD98059 or SP600125 (but not SB203580) at 4h after TNF-alpha microinjected into the RN significantly reversed TNF-alpha-evoked mechanical allodynia. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one tumor necrosis factor Rattus norvegicus