Rotenone

synuclein alpha ; Homo sapiens







89 Article(s)
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51 25497491 Models of α-synuclein aggregation in Parkinson's disease. 2014 Dec 13 1
52 23153578 Expression of human E46K-mutated α-synuclein in BAC-transgenic rats replicates early-stage Parkinson's disease features and enhances vulnerability to mitochondrial impairment. 2013 Feb 1
53 23535362 Specific pesticide-dependent increases in α-synuclein levels in human neuroblastoma (SH-SY5Y) and melanoma (SK-MEL-2) cell lines. 2013 Jun 3
54 23544381 [Neurotoxicity of pesticides: its relationship with neurodegenerative diseases]. 2013 Mar 1
55 23743292 Reprint of: revisiting oxidative stress and mitochondrial dysfunction in the pathogenesis of Parkinson disease-resemblance to the effect of amphetamine drugs of abuse. 2013 Sep 1
56 23984410 Rotenone upregulates alpha-synuclein and myocyte enhancer factor 2D independently from lysosomal degradation inhibition. 2013 3
57 24970188 Biophysical Characterization of α-Synuclein and Rotenone Interaction. 2013 Sep 24 2
58 22319455 The mitochondrial chaperone protein TRAP1 mitigates α-Synuclein toxicity. 2012 Feb 1
59 22967820 Revisiting oxidative stress and mitochondrial dysfunction in the pathogenesis of Parkinson disease--resemblance to the effect of amphetamine drugs of abuse. 2012 Nov 1 1
60 23259041 Rotenone inhibits autophagic flux prior to inducing cell death. 2012 Dec 19 1
61 21238542 Over-expression of α-synuclein 98 triggers intracellular oxidative stress and enhances susceptibility to rotenone. 2011 Mar 17 1
62 21419806 Dose-dependent loss of motor function after unilateral medial forebrain bundle rotenone lesion in rats: a cautionary note. 2011 Sep 12 1
63 21658409 Neuroprotection of α-synuclein under acute and chronic rotenone and maneb treatment is abolished by its familial Parkinson's disease mutations A30P, A53T and E46K. 2011 Dec 2
64 18639366 Synergistic anti-Parkinsonism activity of high doses of B vitamins in a chronic cellular model. 2010 Apr 1
65 19681169 Melatonin treatment potentiates neurodegeneration in a rat rotenone Parkinson's disease model. 2010 Feb 1 1
66 19850127 VPS41, a protein involved in lysosomal trafficking, is protective in Caenorhabditis elegans and mammalian cellular models of Parkinson's disease. 2010 Feb 1
67 19857570 Oxidants induce alternative splicing of alpha-synuclein: Implications for Parkinson's disease. 2010 Feb 1 1
68 20117172 Autophagy protects the rotenone-induced cell death in alpha-synuclein overexpressing SH-SY5Y cells. 2010 Mar 12 3
69 20596942 Dual effects of alpha-synuclein on neurotoxicity induced by low dosage of rotenone are dependent on exposure time in dopaminergic neuroblastoma cells. 2010 May 5
70 20705047 Development of a high-throughput screening assay for cytoprotective agents in rotenone-induced cell death. 2010 Dec 15 1
71 21085094 Oral administration of rotenone using a gavage and image analysis of alpha-synuclein inclusions in the enteric nervous system. 2010 Oct 26 1
72 19385059 A highly reproducible rotenone model of Parkinson's disease. 2009 May 1
73 18562315 Serine 129 phosphorylation of alpha-synuclein induces unfolded protein response-mediated cell death. 2008 Aug 22 2
74 19198139 [Cellular pathophysiology of Parkinson's disease]. 2008 Nov 2
75 16854843 Identification of novel proteins associated with both alpha-synuclein and DJ-1. 2007 May 2
76 16439141 Intersecting pathways to neurodegeneration in Parkinson's disease: effects of the pesticide rotenone on DJ-1, alpha-synuclein, and the ubiquitin-proteasome system. 2006 May 2
77 16579629 Identification of rotenone-induced modifications in alpha-synuclein using affinity pull-down and tandem mass spectrometry. 2006 Apr 1 2
78 17041725 [Overexpression of alpha-synuclein in SH-SY5Y cells partially protected against oxidative stress induced by rotenone]. 2006 Oct 25 4
79 14672949 Proteasome mediates dopaminergic neuronal degeneration, and its inhibition causes alpha-synuclein inclusions. 2004 Mar 12 1
80 15234983 Analysis of alpha-synuclein-associated proteins by quantitative proteomics. 2004 Sep 10 4
81 15280438 Rotenone induces apoptosis via activation of bad in human dopaminergic SH-SY5Y cells. 2004 Dec 3
82 12807439 Alpha-synuclein protects naive but not dbcAMP-treated dopaminergic cell types from 1-methyl-4-phenylpyridinium toxicity. 2003 Jul 1
83 14550906 Alpha-synuclein expression in HEK293 cells enhances the mitochondrial sensitivity to rotenone. 2003 Nov 6 2
84 11679584 Membrane-bound alpha-synuclein has a high aggregation propensity and the ability to seed the aggregation of the cytosolic form. 2002 Jan 4 2
85 11724769 Formation and removal of alpha-synuclein aggregates in cells exposed to mitochondrial inhibitors. 2002 Feb 15 1
86 12151787 Expression of mutant alpha-synucleins enhances dopamine transporter-mediated MPP+ toxicity in vitro. 2002 Jul 19 1
87 12177198 An in vitro model of Parkinson's disease: linking mitochondrial impairment to altered alpha-synuclein metabolism and oxidative damage. 2002 Aug 15 4
88 12548372 Evaluation of risk of Parkinson's disease in a cohort of licensed pesticide users. 2002 Sep 1
89 11445065 Pesticides directly accelerate the rate of alpha-synuclein fibril formation: a possible factor in Parkinson's disease. 2001 Jul 6 2