Title : Neuroprotection of α-synuclein under acute and chronic rotenone and maneb treatment is abolished by its familial Parkinson's disease mutations A30P, A53T and E46K.

Pub. Date : 2011 Dec

PMID : 21658409






2 Functional Relationships(s)
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1 Neuroprotection of alpha-synuclein under acute and chronic rotenone and maneb treatment is abolished by its familial Parkinson"s disease mutations A30P, A53T and E46K. Rotenone synuclein alpha Homo sapiens
2 Compared with untransfected SH-SY5Y cells, wild type alpha-Syn attenuated rotenone and maneb-induced cell death along with an attenuation of toxin-induced mitochondrial membrane potential changes and Reactive Oxygen Species level, whereas the mutant alpha-Syn constructs exacerbated environmental toxins-induced cytotoxicity. Rotenone synuclein alpha Homo sapiens