| 1 |
25567764 | Interaction of Aβ peptide with tubulin causes an inhibition of tubulin polymerization and the apoptotic death of cancer cells. | 2015 Feb 11 |
1 |
| 2 |
17094109 | Mechanisms of guanosine triphosphate hydrolysis by Ras and Ras-GAP proteins as rationalized by ab initio QM/MM simulations. | 2007 Feb 1 |
1 |
| 3 |
15906320 | QM/MM modeling the Ras-GAP catalyzed hydrolysis of guanosine triphosphate. | 2005 Aug 15 |
1 |
| 4 |
15200053 | Comparison of molecular dynamics averaged structures for complexes of normal and oncogenic ras-p21 with SOS nucleotide exchange protein, containing computed conformations for three crystallographically undefined domains, suggests a potential role of these domains in ras signaling. | 2004 Apr |
1 |
| 5 |
11721009 | Molecular dynamics simulations of Gly-12-->Val mutant of p21(ras): dynamic inhibition mechanism. | 2001 Dec |
1 |
| 6 |
10198354 | Gialpha but not gqalpha is linked to activation of p21(ras) in human airway smooth muscle cells. | 1999 Apr |
1 |
| 7 |
10469432 | Hyperactive Ras as a therapeutic target in neurofibromatosis type 1. | 1999 Mar 26 |
1 |
| 8 |
10585950 | Ab initio study of the role of lysine 16 for the molecular switching mechanism of Ras protein p21. | 1999 Dec |
1 |
| 9 |
9624180 | Gbeta gamma-independent coupling of alpha2-adrenergic receptor to p21(rhoA) in preadipocytes. | 1998 Jun 19 |
1 |
| 10 |
9693007 | Raman difference studies of GDP and GTP binding to c-Harvey ras. | 1998 Aug 4 |
1 |
| 11 |
9778364 | Ligand binding is the principal determinant of stability for the p21(H)-ras protein. | 1998 Oct 20 |
1 |
| 12 |
9778365 | The role of ligand binding in the kinetic folding mechanism of human p21(H-ras) protein. | 1998 Oct 20 |
4 |
| 13 |
9878368 | The structure of the Q69L mutant of GDP-Ran shows a major conformational change in the switch II loop that accounts for its failure to bind nuclear transport factor 2 (NTF2). | 1998 Dec 18 |
1 |
| 14 |
9112760 | Inhibition of the GDP/GTP exchange reaction of ras p21 by aluminum ion. | 1997 May 1 |
2 |
| 15 |
9194162 | Comparison of ras-p21 bound to GDP and GTP: differences in protein and ligand dynamics. | 1997 Apr |
3 |
| 16 |
9223188 | Calculation of pathways for the conformational transition between the GTP- and GDP-bound states of the Ha-ras-p21 protein: calculations with explicit solvent simulations and comparison with calculations in vacuum. | 1997 Jul |
2 |
| 17 |
9287316 | Equilibrium and kinetic study of the conformational transition toward the active state of p21Ha-ras, induced by the binding of BeF3- to the GDP-bound state, in the absence of GTPase-activating proteins. | 1997 Sep 12 |
1 |
| 18 |
9309221 | The frozen solution structure of p21 ras determined by ESEEM spectroscopy reveals weak coordination of Thr35 to the active site metal ion. | 1997 Aug 15 |
1 |
| 19 |
9374488 | Nucleotide hydrolysis-dependent conformational changes in p21(ras) as studied using ESR spectroscopy. | 1997 Nov 28 |
1 |
| 20 |
9398520 | Ligand-induced conformational changes in ras p21: a normal mode and energy minimization analysis. | 1997 Nov 21 |
1 |
| 21 |
8810926 | High frequency (139.5 GHz) electron paramagnetic resonance characterization of Mn(II)-H2(17)O interactions in GDP and GTP forms of p21 ras. | 1996 Sep 17 |
2 |
| 22 |
8832375 | Oncogenic amino acid substitutions in the inhibitory rap-1A protein cause it to adopt a ras-p21-like conformation as computed using molecular dynamics. | 1996 Jun |
1 |
| 23 |
8838585 | Prediction of the three-dimensional structure of the rap-1A protein from its homology to the ras-gene-encoded p21 protein. | 1996 Jan |
3 |
| 24 |
8983024 | Positive and negative modulation of H-ras transforming potential by mutations of phenylalanine-28. | 1996 |
1 |
| 25 |
7547942 | Molecular dynamics simulation of the solution structures of Ha-ras-p21 GDP and GTP complexes: flexibility, possible hinges, and levers of the conformational transition. | 1995 Sep 19 |
2 |
| 26 |
7547978 | Characterization of mammalian C-CDC25Mm exchange factor and kinetic properties of the exchange reaction intermediate p21.C-CDC25Mm. | 1995 Sep 26 |
4 |
| 27 |
7647555 | The effect of 17O on the relaxation of an amide proton within a hydrogen bond. | 1995 Jun |
1 |
| 28 |
7851434 | Properties of the catalytic domain of sdc25p, a yeast GDP/GTP exchange factor of Ras proteins. Complexation with wild-type Ras2p, [S24N]Ras2p and [R80D, N81D]Ras2p. | 1995 Jan 15 |
2 |
| 29 |
8593186 | Comparison of the computed three-dimensional structures of oncogenic forms (bound to GDP) of the ras-gene-encoded p21 protein with the structure of the normal (non-transforming) wild-type protein. | 1995 Aug |
2 |
| 30 |
8607982 | Ras-related proteins in signal transduction and growth control. | 1995 Dec |
1 |
| 31 |
8747433 | Structural effects of the binding of GTP to the wild-type and oncogenic forms of the ras-gene-encoded p21 proteins. | 1995 Nov |
1 |
| 32 |
7819095 | Haemoglobin inhibits GTP-hydrolysis and GDP/GTP-exchange activities of a low M(r) GTP-binding protein, ras p21. | 1994 Dec |
4 |
| 33 |
7853016 | Changing expression of GTPase activating proteins with differentiation in neuroblastoma. | 1994 Nov |
1 |
| 34 |
7961601 | The hydration of Ras p21 in solution during GTP hydrolysis based on solution X-ray scattering profile. | 1994 May |
2 |
| 35 |
8060496 | Comparison of the low energy conformations of an oncogenic and a non-oncogenic p21 protein, neither of which binds GTP or GDP. | 1994 Feb |
4 |
| 36 |
8137813 | Inhibition of rab5 GTPase activity stimulates membrane fusion in endocytosis. | 1994 Mar 15 |
1 |
| 37 |
8139548 | rac p21 is involved in insulin-induced membrane ruffling and rho p21 is involved in hepatocyte growth factor- and 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced membrane ruffling in KB cells. | 1994 Apr |
3 |
| 38 |
8142349 | Solution structure and dynamics of ras p21.GDP determined by heteronuclear three- and four-dimensional NMR spectroscopy. | 1994 Mar 29 |
1 |
| 39 |
8142406 | Characterization of the active site of p21 ras by electron spin-echo envelope modulation spectroscopy with selective labeling: comparisons between GDP and GTP forms. | 1994 Apr 5 |
1 |
| 40 |
8142894 | Hydrogen bond interactions of G proteins with the guanine ring moiety of guanine nucleotides. | 1994 Jan |
1 |
| 41 |
8144711 | SPROUT: recent developments in the de novo design of molecules. | 1994 Jan-Feb |
1 |
| 42 |
8129867 | Molecular dynamics of the H-ras gene-encoded p21 protein; identification of flexible regions and possible effector domains. | 1993 Dec |
1 |
| 43 |
8226937 | Consequences of weak interaction of rho GDI with the GTP-bound forms of rho p21 and rac p21. | 1993 Nov 15 |
3 |
| 44 |
8244990 | Comparison of kinetic properties between two mammalian ras p21 GDP/GTP exchange proteins, ras guanine nucleotide-releasing factor and smg GDP dissociation stimulation. | 1993 Dec 5 |
1 |
| 45 |
8318164 | Activated conformations of the ras-gene-encoded p21 protein. 2. Comparison of the computed and high-resolution x-ray crystallographic structures of Gly-12 p21. | 1993 Apr |
6 |
| 46 |
8329399 | Mapping the nucleotide-dependent conformational change of human N-ras p21 in solution by heteronuclear-edited proton-observed NMR methods. | 1993 Jul 6 |
2 |
| 47 |
8338843 | Mechanism of GTP hydrolysis by p21N-ras catalyzed by GAP: studies with a fluorescent GTP analogue. | 1993 Jul 27 |
1 |
| 48 |
8352776 | The nucleotide exchange rates of rho and rac small GTP-binding proteins are enhanced to different extents by their regulatory protein Smg GDS. | 1993 Aug 16 |
5 |
| 49 |
8386636 | Nucleotide binding and GTP hydrolysis by the 21-kDa product of the c-H-ras gene as monitored by proton-NMR spectroscopy. | 1993 Apr 15 |
1 |
| 50 |
8393791 | Affinity labeling of c-H-ras p21 consensus elements with periodate-oxidized GDP and GTP. | 1993 Jul 15 |
3 |