Title : Activated conformations of the ras-gene-encoded p21 protein. 2. Comparison of the computed and high-resolution x-ray crystallographic structures of Gly-12 p21.

Pub. Date : 1993 Apr

PMID : 8318164






6 Functional Relationships(s)
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Protein Name
Organism
1 p21 is thought to be activated by the binding of GTP in place of GDP to the protein. Guanosine Diphosphate H3 histone pseudogene 16 Homo sapiens
2 We have previously constructed the three-dimensional structure of the p21 protein bound to GDP from an available alpha-carbon tracing of this protein using a combination of molecular dynamics and energy minimization (Dykes, et al., J. Biomol. Guanosine Diphosphate H3 histone pseudogene 16 Homo sapiens
3 In this communication we compare our computed structure for the p21-GDP complex to this x-ray crystal structure. Guanosine Diphosphate H3 histone pseudogene 16 Homo sapiens
4 Both of these regions have been found in x-ray crystallographic studies of p21-GDP and p21-GTP complexes to undergo significant changes in conformation upon the binding of GTP in place of GDP to the protein. Guanosine Diphosphate H3 histone pseudogene 16 Homo sapiens
5 Both of these regions have been found in x-ray crystallographic studies of p21-GDP and p21-GTP complexes to undergo significant changes in conformation upon the binding of GTP in place of GDP to the protein. Guanosine Diphosphate H3 histone pseudogene 16 Homo sapiens
6 Both of these regions have been found in x-ray crystallographic studies of p21-GDP and p21-GTP complexes to undergo significant changes in conformation upon the binding of GTP in place of GDP to the protein. Guanosine Diphosphate H3 histone pseudogene 16 Homo sapiens