2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one

insulin like growth factor 1 ; Homo sapiens







63 Article(s)
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1 33035625 Anti-inflammatory effect of IGF-1 is mediated by IGF-1R cross talk with GPER in MPTP/MPP+-induced astrocyte activation. 2021 Jan 1 1
2 30987295 Mel1c Mediated Monochromatic Light-Stimulated IGF-I Synthesis through the Intracellular Gαq/PKC/ERK Signaling Pathway. 2019 Apr 4 1
3 30233784 Repression of IGF-I-induced osteoblast migration by (-)-epigallocatechin gallate through p44/p42 MAP kinase signaling. 2018 Oct 1
4 27090441 The protective effects of insulin-like growth factor-1 on neurochemical phenotypes of dorsal root ganglion neurons with BDE-209-induced neurotoxicity in vitro. 2017 Mar 1
5 26084532 Early Growth Response Protein-1 Expression by Insulin-Like Growth Factor-1 Requires ROS-Dependent Activation of ERK1/2 and PKB Pathways in Vascular Smooth Muscle Cells. 2016 Jan 2
6 24243530 Role of heterotrimeric G protein and calcium in cardiomyocyte hypertrophy induced by IGF-1. 2014 Apr 1
7 22186070 Mechano-growth factor E peptide inhibits the differentiation and mineralization of osteoblasts. 2012 Jun 1
8 21448845 Differential roles of MAPK-Erk1/2 and MAPK-p38 in insulin or insulin-like growth factor-I (IGF-I) signaling pathways for progesterone production in human ovarian cells. 2011 Jun 1
9 21904903 PI3K/Akt and MAPK/ERK1/2 signaling pathways are involved in IGF-1-induced VEGF-C upregulation in breast cancer. 2011 Nov 1
10 22440707 Involvement of the metabolic hormones leptin, ghrelin, obestatin, IGF-I and of MAP kinase in control of porcine oocyte maturation. 2011 Jan 2
11 20110686 C2 skeletal myoblast survival, death, proliferation and differentiation: regulation by Adra1d. 2010 1
12 20485667 Rapamycin inhibits IGF-1 stimulated cell motility through PP2A pathway. 2010 May 11 1
13 20517899 Insulin stimulates osteoblast proliferation and differentiation through ERK and PI3K in MG-63 cells. 2010 Jun 1
14 19254730 Fluvastatin attenuates IGF-1-induced ERK1/2 activation and cell proliferation by mevalonic acid depletion in human mesangial cells. 2009 May 22 1
15 19639579 Up-regulation of the tight-junction protein ZO-1 by substance P and IGF-1 in A431 cells. 2009 Aug 2
16 19895315 MAP kinase pathway is involved in IGF-1-stimulated proliferation of human retinal pigment epithelial cells (hRPE). 2009 Oct 3
17 18651291 Pro- and anti-apoptotic roles for IGF-I in TNF-alpha-induced apoptosis: a MAP kinase mediated mechanism. 2008 Oct 1
18 17348861 IGF-I-induced oligodendrocyte progenitor proliferation requires PI3K/Akt, MEK/ERK, and Src-like tyrosine kinases. 2007 Mar 1
19 17592551 Survivin expression in tuberous sclerosis complex cells. 2007 Mar-Apr 1
20 17624368 Angiotensin II and IGF-1 regulate connexin43 expression via ERK and p38 signaling pathways in vascular smooth muscle cells of coronary artery bypass conduits. 2007 Sep 1
21 17956673 [Effect of MAPK signaling pathway phosphorylation on proliferation of myeloma cell line KM3 by insulin-like growth factor 1]. 2007 Oct 1
22 16403461 Insulin-like growth factor-I-coupled mitogenic signaling in primary cultured human skeletal muscle cells and in C2C12 myoblasts. A central role of protein kinase Cdelta. 2006 Sep 2
23 16412381 IGF-I-induced VEGF expression in HUVEC involves phosphorylation and inhibition of poly(ADP-ribose)polymerase. 2006 Mar 3 1
24 17129375 Abnormal insulin-like growth factor 1 signaling in human osteoarthritic subchondral bone osteoblasts. 2006 1
25 15767261 Cooperation of amphiregulin and insulin-like growth factor-1 inhibits Bax- and Bad-mediated apoptosis via a protein kinase C-dependent pathway in non-small cell lung cancer cells. 2005 May 20 1
26 15801908 IGF-I stimulation of proteoglycan synthesis by chondrocytes requires activation of the PI 3-kinase pathway but not ERK MAPK. 2005 Aug 1 1
27 15909115 Sustained Akt/PKB activation and transient attenuation of c-jun N-terminal kinase in the inhibition of apoptosis by IGF-1 in vascular smooth muscle cells. 2005 May 1
28 15922332 Insulin and IGF-1 regulate the expression of the pituitary tumor transforming gene (PTTG) in breast tumor cells. 2005 Jun 6 1
29 14697248 Overexpression of ErbB2 receptor inhibits IGF-I-induced Shc-MAPK signaling pathway in breast cancer cells. 2004 Jan 16 1
30 15140184 Comparative signaling pathways of insulin-like growth factor-1 and brain-derived neurotrophic factor in hippocampal neurons and the role of the PI3 kinase pathway in cell survival. 2004 May 1
31 15659801 Role of constitutively activated and insulin-like growth factor-stimulated ERK1/2 signaling in human hepatoma cell proliferation and apoptosis: evidence for heterogeneity of tumor cell lines. 2004 Dec 1
32 12647305 Involvement of MEKK1/ERK/P21Waf1/Cip1 signal transduction pathway in inhibition of IGF-I-mediated cell growth response by methylglyoxal. 2003 Apr 15 1
33 12843192 The role of mitogen-activated protein kinase in insulin and insulin-like growth factor I (IGF-I) signaling cascades for progesterone and IGF-binding protein-1 production in human granulosa cells. 2003 Jul 6
34 12930919 Insulin-like growth factor I promotes maturation and inhibits apoptosis of immature cord blood monocyte-derived dendritic cells through MEK and PI 3-kinase pathways. 2003 Dec 1
35 12943991 The chemotactic and mitogenic responses of vascular smooth muscle cells to insulin-like growth factor-I require the activation of ERK1/2. 2003 Aug 29 2
36 14522909 Insulin-like growth factor-1 induces adhesion and migration in human multiple myeloma cells via activation of beta1-integrin and phosphatidylinositol 3'-kinase/AKT signaling. 2003 Sep 15 1
37 11787050 IGF-1 induces Pin1 expression in promoting cell cycle S-phase entry. 2002 1
38 11839539 Insulin-like growth factor I receptor is downregulated after alveolarization in an apoptotic fibroblast subset. 2002 Mar 1
39 12167664 Phosphatidylinositol 3-kinase/Akt pathway regulates tuberous sclerosis tumor suppressor complex by phosphorylation of tuberin. 2002 Sep 20 1
40 12204896 Insulin-like growth factor-I inhibits cell growth in the a549 non-small lung cancer cell line. 2002 Sep 1
41 12359775 Multiple mitogenic pathways in pancreatic cancer cells are blocked by a truncated epidermal growth factor receptor. 2002 Oct 1 1
42 11245436 Up-regulation of urokinase-type plasminogen activator by insulin-like growth factor-I depends upon phosphatidylinositol-3 kinase and mitogen-activated protein kinase kinase. 2001 Feb 15 2
43 11313952 Insulin and IGF-1 stimulate the beta-catenin pathway through two signalling cascades involving GSK-3beta inhibition and Ras activation. 2001 Jan 11 1
44 11594774 Insulin, insulin-like growth factor-I, and platelet-derived growth factor activate extracellular signal-regulated kinase by distinct pathways in muscle cells. 2001 Oct 19 1
45 10646854 N-Myc induction stimulated by insulin-like growth factor I through mitogen-activated protein kinase signaling pathway in human neuroblastoma cells. 2000 Jan 1 2
46 10675492 Autocrine secreted insulin-like growth factor-I stimulates MAP kinase-dependent mitogenic effects in human primitive neuroectodermal tumor/medulloblastoma. 2000 Mar 1
47 10707862 Phosphatidylinositol-3 kinase and extracellular signal-regulated kinase mediate the chemotactic and mitogenic effects of insulin-like growth factor-I in human hepatic stellate cells. 2000 Feb 1
48 10764740 Two different signal transduction pathways are implicated in the regulation of initiation factor 2B activity in insulin-like growth factor-1-stimulated neuronal cells. 2000 Jun 23 1
49 10777488 Insulin and insulin-like growth factor-I induce vascular endothelial growth factor mRNA expression via different signaling pathways. 2000 Jul 14 1
50 10873605 IGF-1 regulates cardiac fibroblast apoptosis induced by osmotic stress. 2000 Jun 24 1