Title : Insulin and IGF-1 stimulate the beta-catenin pathway through two signalling cascades involving GSK-3beta inhibition and Ras activation.

Pub. Date : 2001 Jan 11

PMID : 11313952






1 Functional Relationships(s)
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1 The Ras signalling pathway was also required as (i) the stimulatory effects of insulin and IGF-1 were inhibited by dominant-negative Ras or the MEK1 inhibitor PD98059 and (ii) activated Ha-Ras or constitutively active MEK1 synergized with catalytically inactive GSK-3beta to stimulate Lef/Tcf-dependent transcription. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one insulin like growth factor 1 Homo sapiens