Title : Up-regulation of the tight-junction protein ZO-1 by substance P and IGF-1 in A431 cells.

Pub. Date : 2009 Aug

PMID : 19639579






2 Functional Relationships(s)
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1 The SP- and IGF-1-induced up-regulation of ZO-1 was accompanied by phosphorylation of extracellular signal-regulated kinase (ERK), and both of these effects were blocked by PD98059, an inhibitor of ERK activation. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one insulin like growth factor 1 Homo sapiens
2 SP and IGF-1 also increased the transepithelial electrical resistance (TER) (an indicator of barrier function) of an A431 cell monolayer in a manner sensitive to PD98059. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one insulin like growth factor 1 Homo sapiens