Title : Insulin-like growth factor I receptor is downregulated after alveolarization in an apoptotic fibroblast subset.

Pub. Date : 2002 Mar

PMID : 11839539






1 Functional Relationships(s)
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1 Treatment with anti-IGF-IR decreased total lung fibroblast survival (P = 0.05) as did treatment with the phosphatidylinositol 3-kinase inhibitor LY-294002 and the ras-raf-mitogen-activated protein kinase inhibitor PD-98059 (P < 0.002), which block IGF-I/insulin receptor survival pathways. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one insulin like growth factor 1 Homo sapiens