| 1 |
35192728 | Poloxamer-linked prodrug of a topoisomerase I inhibitor SN22 shows efficacy in models of high-risk neuroblastoma with primary and acquired chemoresistance. | 2022 Mar |
1 |
| 2 |
31482012 | Transcription-independent and -dependent p53-mediated apoptosis in response to genotoxic and non-genotoxic stress. | 2019 |
6 |
| 3 |
29684847 | The association between p53 protein phosphorylation at serine 15, serine 20 and sensitivity of cells isolated from patients with ovarian cancer and cell lines to chemotherapy in in vitro study. | 2018 Jun |
3 |
| 4 |
29875999 | Transcriptional activation of p21Waf1 contributes to suppression of HR by p53 in response to replication arrest induced by camptothecin. | 2018 May 22 |
1 |
| 5 |
30096294 | PIM2 survival kinase is upregulated in a p53-dependent manner in cells treated with camptothecin or co-treated with actinomycin D and nutlin-3a. | 2018 Oct 1 |
1 |
| 6 |
28361991 | Y14 governs p53 expression and modulates DNA damage sensitivity. | 2017 Mar 31 |
1 |
| 7 |
29137250 | Molecular chaperones in the acquisition of cancer cell chemoresistance with mutated TP53 and MDM2 up-regulation. | 2017 Oct 10 |
1 |
| 8 |
26252178 | Decrease of mitochondrial p53 during late apoptosis is linked to its dephosphorylation on serine 20. | 2015 |
1 |
| 9 |
26437226 | Identification of novel, in vivo active Chk1 inhibitors utilizing structure guided drug design. | 2015 Nov 3 |
1 |
| 10 |
24726431 | SIRT1 inhibition restores apoptotic sensitivity in p53-mutated human keratinocytes. | 2014 Jun 15 |
1 |
| 11 |
24786831 | Proline, glutamic acid and leucine-rich protein-1 is essential for optimal p53-mediated DNA damage response. | 2014 Sep |
1 |
| 12 |
24858802 | Autophagy inhibition switches low-dose camptothecin-induced premature senescence to apoptosis in human colorectal cancer cells. | 2014 Aug 1 |
2 |
| 13 |
24996846 | γH2AX and Chk1 phosphorylation as predictive pharmacodynamic biomarkers of Chk1 inhibitor-chemotherapy combination treatments. | 2014 Jul 4 |
1 |
| 14 |
23006513 | Topoisomerase degradation, DSB repair, p53 and IAPs in cancer cell resistance to camptothecin-like topoisomerase I inhibitors. | 2013 Jan |
1 |
| 15 |
23161404 | Pharmacological inhibition of GSK3 attenuates DNA damage-induced apoptosis via reduction of p53 mitochondrial translocation and Bax oligomerization in neuroblastoma SH-SY5Y cells. | 2013 Mar |
2 |
| 16 |
23208500 | Induction of p53, p21 and apoptosis by silencing the NF90/NF45 complex in human papilloma virus-transformed cervical carcinoma cells. | 2013 Oct 24 |
1 |
| 17 |
23313858 | Sirt1 attenuates camptothecin-induced apoptosis through caspase-3 pathway in porcine preadipocytes. | 2013 Mar 10 |
2 |
| 18 |
23470959 | DDX3 regulates DNA damage-induced apoptosis and p53 stabilization. | 2013 Jun |
4 |
| 19 |
23536184 | The Arf/p53 protein module, which induces apoptosis, down-regulates histone H2AX to allow normal cells to survive in the presence of anti-cancer drugs. | 2013 May 10 |
1 |
| 20 |
24219989 | Acetylation of p53 stimulates miRNA processing and determines cell survival following genotoxic stress. | 2013 Dec 11 |
2 |
| 21 |
20812030 | Mdm2 inhibition induces apoptosis in p53 deficient human colon cancer cells by activating p73- and E2F1-mediated expression of PUMA and Siva-1. | 2011 Jan |
2 |
| 22 |
21145583 | Activation of stress-regulated transcription factors by triethylene glycol dimethacrylate monomer. | 2011 Mar |
3 |
| 23 |
21809047 | Camptothecin induces p53-dependent and -independent apoptogenic signaling in melanoma cells. | 2011 Nov |
1 |
| 24 |
19629643 | Differential regulation of Apak by various DNA damage signals. | 2010 Jan |
2 |
| 25 |
20042274 | ATM- and ATR-mediated response to DNA damage induced by a novel camptothecin, ST1968. | 2010 Jun 28 |
1 |
| 26 |
20086182 | The six-nucleotide deletion/insertion variant in the CASP8 promoter region is inversely associated with risk of squamous cell carcinoma of the head and neck. | 2010 Feb |
1 |
| 27 |
20429622 | Dual inhibition of topoisomerases enhances apoptosis in melanoma cells. | 2010 |
1 |
| 28 |
20661218 | Restoration of the tumor suppressor p53 by downregulating cyclin B1 in human papillomavirus 16/18-infected cancer cells. | 2010 Oct 14 |
1 |
| 29 |
20662736 | Characterization and optimization of a novel protein-protein interaction biosensor high-content screening assay to identify disruptors of the interactions between p53 and hDM2. | 2010 Aug |
2 |
| 30 |
20978201 | DNA damage recognition via activated ATM and p53 pathway in nonproliferating human prostate tissue. | 2010 Nov 1 |
1 |
| 31 |
19049493 | The tumour suppressor p53 regulates the expression of amyloid precursor protein (APP). | 2009 Mar 15 |
1 |
| 32 |
19060337 | Dual regulation of Cdc25A by Chk1 and p53-ATF3 in DNA replication checkpoint control. | 2009 Feb 13 |
1 |
| 33 |
19261878 | Histone deacetylase inhibitors prevent p53-dependent and p53-independent Bax-mediated neuronal apoptosis through two distinct mechanisms. | 2009 Mar 4 |
2 |
| 34 |
19445707 | Increased susceptibility of spinal muscular atrophy fibroblasts to camptothecin is p53-independent. | 2009 May 16 |
3 |
| 35 |
18208837 | Regulation of the human AP-endonuclease (APE1/Ref-1) expression by the tumor suppressor p53 in response to DNA damage. | 2008 Mar |
1 |
| 36 |
18418047 | A role of HAUSP in tumor suppression in a human colon carcinoma xenograft model. | 2008 May 1 |
1 |
| 37 |
18495890 | CITED2 signals through peroxisome proliferator-activated receptor-gamma to regulate death of cortical neurons after DNA damage. | 2008 May 21 |
1 |
| 38 |
17255282 | CHIR-124, a novel potent inhibitor of Chk1, potentiates the cytotoxicity of topoisomerase I poisons in vitro and in vivo. | 2007 Jan 15 |
1 |
| 39 |
17317670 | Antiproliferative autoantigen CDA1 transcriptionally up-regulates p21(Waf1/Cip1) by activating p53 and MEK/ERK1/2 MAPK pathways. | 2007 Apr 20 |
1 |
| 40 |
17555331 | Human p53 is inhibited by glutathionylation of cysteines present in the proximal DNA-binding domain during oxidative stress. | 2007 Jul 3 |
1 |
| 41 |
17709397 | Regulation of H-ras splice variant expression by cross talk between the p53 and nonsense-mediated mRNA decay pathways. | 2007 Oct |
2 |
| 42 |
16319068 | Camptothecin induces nuclear export of prohibitin preferentially in transformed cells through a CRM-1-dependent mechanism. | 2006 Feb 3 |
1 |
| 43 |
16407843 | p21CDKN1A allows the repair of replication-mediated DNA double-strand breaks induced by topoisomerase I and is inactivated by the checkpoint kinase inhibitor 7-hydroxystaurosporine. | 2006 May 11 |
2 |
| 44 |
15674334 | Tumor suppressor p53 represses transcription of RECQ4 helicase. | 2005 Mar 3 |
2 |
| 45 |
15846088 | Inhibition of p53 by lentiviral mediated shRNA abrogates G1 arrest and apoptosis in retinal pigmented epithelial cell line. | 2005 May |
1 |
| 46 |
15908423 | A chromatin-associated and transcriptionally inactive p53-Mdm2 complex occurs in mdm2 SNP309 homozygous cells. | 2005 Jul 22 |
1 |
| 47 |
15958570 | Sensitization of glioma cells to Fas-dependent apoptosis by chemotherapy-induced oxidative stress. | 2005 Jun 15 |
1 |
| 48 |
15149862 | Distinct functions for WRN and TP53 in a shared pathway of cellular response to 1-beta-D-arabinofuranosylcytosine and bleomycin. | 2004 Jun 10 |
1 |
| 49 |
15208667 | p53-dependent transcription can exhibit both on/off and graded response after genotoxic stress. | 2004 Aug 19 |
1 |
| 50 |
15371552 | Down-regulation of MDM2 and activation of p53 in human cancer cells by antisense 9-aminoacridine-PNA (peptide nucleic acid) conjugates. | 2004 |
1 |