Title : p21CDKN1A allows the repair of replication-mediated DNA double-strand breaks induced by topoisomerase I and is inactivated by the checkpoint kinase inhibitor 7-hydroxystaurosporine.

Pub. Date : 2006 May 11

PMID : 16407843






2 Functional Relationships(s)
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1 We report that defects of p21(CDKN1A) and p53 enhance camptothecin-induced histone H2AX phosphorylation (gammaH2AX), a marker for DNA DSBs. Camptothecin tumor protein p53 Homo sapiens
2 In human colon carcinoma HCT116 cells with wild-type (wt) p53, gammaH2AX reverses after camptothecin removal. Camptothecin tumor protein p53 Homo sapiens