Title : Distinct functions for WRN and TP53 in a shared pathway of cellular response to 1-beta-D-arabinofuranosylcytosine and bleomycin.

Pub. Date : 2004 Jun 10

PMID : 15149862






1 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Mutations in the WRN or the TP53 genes lead to spontaneous genetic instability, an elevated risk of tumor formation, and sensitivity to compounds that interfere with DNA replication, such as camptothecin and DNA interstrand cross-linking drugs. Camptothecin tumor protein p53 Homo sapiens