Silybin

tumor protein p53 ; Homo sapiens







25 Article(s)
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Title
Pub. Year
#Total Relationships
1 34053323 Autophagy and glycolysis independently attenuate silibinin-induced apoptosis in human hepatocarcinoma HepG2 and Hep3B cells. 2021 Dec 2
2 32670818 Silibinin and non-melanoma skin cancers. 2020 May 1
3 28884602 Enhancement of anticancer activity by silibinin and paclitaxel combination on the ovarian cancer. 2018 Nov 1
4 30205806 Silimarin and Cancer. 2018 1
5 28119262 Silibinin induces hepatic stellate cell cycle arrest via enhancing p53/p27 and inhibiting Akt downstream signaling protein expression. 2017 Feb 2
6 28229968 Cytotoxic and toxicogenomic effects of silibinin in bladder cancer cells with different TP53 status. 2017 Mar 5
7 25750273 The effect of silibinin in enhancing toxicity of temozolomide and etoposide in p53 and PTEN-mutated resistant glioma cell lines. 2015 Mar 2
8 25773855 Silibilin-induces apoptosis in breast cancer cells by modulating p53, p21, Bak and Bcl-XL pathways. 2015 1
9 26097804 An Overview of Ultraviolet B Radiation-Induced Skin Cancer Chemoprevention by Silibinin. 2015 Jun 1 1
10 26447614 Silibinin enhances the repair of ultraviolet B-induced DNA damage by activating p53-dependent nucleotide excision repair mechanism in human dermal fibroblasts. 2015 Nov 24 4
11 24440808 Silibinin induces apoptosis of HT29 colon carcinoma cells through early growth response-1 (EGR-1)-mediated non-steroidal anti-inflammatory drug-activated gene-1 (NAG-1) up-regulation. 2014 Mar 25 4
12 24798868 Inhibition of SIRT1 signaling sensitizes the antitumor activity of silybin against human lung adenocarcinoma cells in vitro and in vivo. 2014 Jul 1
13 22619007 Silibinin triggers apoptosis and cell-cycle arrest of SGC7901 cells. 2013 Mar 1
14 22166495 Silibinin prevents ultraviolet B radiation-induced epidermal damages in JB6 cells and mouse skin in a p53-GADD45α-dependent manner. 2012 Mar 5
15 22283740 P53 activation plays a crucial role in silibinin induced ROS generation via PUMA and JNK. 2012 Mar 10
16 22607092 P53-mediated GSH depletion enhanced the cytotoxicity of NO in silibinin-treated human cervical carcinoma HeLa cells. 2012 Sep 5
17 21166494 Silibinin-induced apoptosis in MCF7 and T47D human breast carcinoma cells involves caspase-8 activation and mitochondrial pathway. 2011 Jan 1
18 21212516 Silibinin activated p53 and induced autophagic death in human fibrosarcoma HT1080 cells via reactive oxygen species-p38 and c-Jun N-terminal kinase pathways. 2011 6
19 21262221 Mechanism of autophagy induction and role of autophagy in antagonizing mitomycin C-induced cell apoptosis in silibinin treated human melanoma A375-S2 cells. 2011 May 20 5
20 19834285 The protective effect of silibinin against mitomycin C-induced intrinsic apoptosis in human melanoma A375-S2 cells. 2009 Oct 1
21 18172282 Oral silibinin inhibits in vivo human bladder tumor xenograft growth involving down-regulation of survivin. 2008 Jan 1 1
22 18723275 Silibinin inhibits cell growth and induces apoptosis by caspase activation, down-regulating survivin and blocking EGFR-ERK activation in renal cell carcinoma. 2008 Dec 8 1
23 16777994 Silibinin activates p53-caspase 2 pathway and causes caspase-mediated cleavage of Cip1/p21 in apoptosis induction in bladder transitional-cell papilloma RT4 cells: evidence for a regulatory loop between p53 and caspase 2. 2006 Nov 8
24 15713892 Silymarin induces apoptosis primarily through a p53-dependent pathway involving Bcl-2/Bax, cytochrome c release, and caspase activation. 2005 Feb 1
25 16084079 Mechanisms and preclinical efficacy of silibinin in preventing skin cancer. 2005 Sep 1