Pub. Date : 2006 Nov
PMID : 16777994
8 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Silibinin activates p53-caspase 2 pathway and causes caspase-mediated cleavage of Cip1/p21 in apoptosis induction in bladder transitional-cell papilloma RT4 cells: evidence for a regulatory loop between p53 and caspase 2. | Silybin | tumor protein p53 | Homo sapiens |
| 2 | Silibinin activates p53-caspase 2 pathway and causes caspase-mediated cleavage of Cip1/p21 in apoptosis induction in bladder transitional-cell papilloma RT4 cells: evidence for a regulatory loop between p53 and caspase 2. | Silybin | tumor protein p53 | Homo sapiens |
| 3 | Here, we studied the mechanisms involved in silibinin-induced apoptosis of RT4 cells having intact p53. | Silybin | tumor protein p53 | Homo sapiens |
| 4 | Silibinin increased p53 protein level together with its increased phosphorylation at serine 15, activated caspase cascade and caused Bid cleavage for apoptosis. | Silybin | tumor protein p53 | Homo sapiens |
| 5 | Silibinin-caused p53 activation was mediated via ATM-Chk2 pathway, which in turn induced caspase 2-mediated apoptosis. | Silybin | tumor protein p53 | Homo sapiens |
| 6 | Pifithrin-alpha, a p53 inhibitor, reversed silibinin-induced caspase activation including caspase 2; however, caspase 2 inhibitor also reversed p53 phosphorylation suggesting a bidirectional regulation between them. | Silybin | tumor protein p53 | Homo sapiens |
| 7 | Further, silibinin caused a rapid translocation of p53 and Bid into mitochondria leading to increased permeabilization of mitochondrial membrane and cytochrome c release into the cytosol. | Silybin | tumor protein p53 | Homo sapiens |
| 8 | Together, these results suggested the novel mechanisms for apoptosis induction by silibinin involving p53-caspase 2 activation and caspase-mediated cleavage of Cip1/p21. | Silybin | tumor protein p53 | Homo sapiens |