Pub. Date : 2012 Mar
PMID : 22166495
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | In mechanistic studies, UVB-irradiated cells showed a transient upregulation of both phosphorylated (Ser-15 and Ser-392) and total p53, whereas silibinin pretreatment led to a more sustained upregulation and stronger nuclear localization of p53. | Silybin | tumor protein p53 | Homo sapiens |
| 2 | Silibinin also caused a marked upregulation of GADD45alpha, a downstream target of p53, implicated in DNA repair and cell cycle regulation. | Silybin | tumor protein p53 | Homo sapiens |
| 3 | Importantly, under p53 and GADD45alpha knockdown conditions, cells were more susceptible to UVB-induced apoptosis without any significant S phase arrest, and protective effects of silibinin were compromised. | Silybin | tumor protein p53 | Homo sapiens |
| 4 | Together, our results show for the first time that p53-mediated GADD45alpha upregulation is the key mechanism by which silibinin protects against UVB-induced photodamage and provides a strong rationale to investigate silibinin in reducing the risk and/or preventing early onset of NMSC. | Silybin | tumor protein p53 | Homo sapiens |
| 5 | Together, our results show for the first time that p53-mediated GADD45alpha upregulation is the key mechanism by which silibinin protects against UVB-induced photodamage and provides a strong rationale to investigate silibinin in reducing the risk and/or preventing early onset of NMSC. | Silybin | tumor protein p53 | Homo sapiens |