Pub. Date : 2012 Mar
PMID : 22283740
10 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | P53 activation plays a crucial role in silibinin induced ROS generation via PUMA and JNK. | Silybin | tumor protein p53 | Homo sapiens |
| 2 | Silibinin promoted the expression phosphorylated-p53 (p-p53) in a dose-dependent manner. | Silybin | tumor protein p53 | Homo sapiens |
| 3 | Silibinin promoted the expression phosphorylated-p53 (p-p53) in a dose-dependent manner. | Silybin | tumor protein p53 | Homo sapiens |
| 4 | Pifithrin-alpha (PFT-alpha), a specific inhibitor of p53, reduced ROS production and reversed silibinin"s growth-inhibitory effect. | Silybin | tumor protein p53 | Homo sapiens |
| 5 | The ROS scavenger N-acetyl cysteine (NAC) attenuated silibinin-induced up-regulation of p-p53 expression, suggesting that p53 might be regulated by ROS and forms a positive feedback loop with ROS. | Silybin | tumor protein p53 | Homo sapiens |
| 6 | The ROS scavenger N-acetyl cysteine (NAC) attenuated silibinin-induced up-regulation of p-p53 expression, suggesting that p53 might be regulated by ROS and forms a positive feedback loop with ROS. | Silybin | tumor protein p53 | Homo sapiens |
| 7 | Activation of p53 was suppressed by SP600125 and expression of p-JNK was inhibited by PFT-alpha, therefore silibinin might activate a ROS-JNK-p53 cycle to induce cell death. | Silybin | tumor protein p53 | Homo sapiens |
| 8 | Activation of p53 was suppressed by SP600125 and expression of p-JNK was inhibited by PFT-alpha, therefore silibinin might activate a ROS-JNK-p53 cycle to induce cell death. | Silybin | tumor protein p53 | Homo sapiens |
| 9 | In order to elucidate the functions of p53 in silibinin induced ROS generation, we have chosen the A431 cells (human epithelial carcinoma) because they lack p53 activity (p53His273 mutation). | Silybin | tumor protein p53 | Homo sapiens |
| 10 | p53 activation plays a crucial role in silibinin induced ROS generation. | Silybin | tumor protein p53 | Homo sapiens |