Pub. Date : 2015 Nov 24
PMID : 26447614
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Silibinin enhances the repair of ultraviolet B-induced DNA damage by activating p53-dependent nucleotide excision repair mechanism in human dermal fibroblasts. | Silybin | tumor protein p53 | Homo sapiens |
| 2 | In UVB exposed fibroblasts, silibinin treatment also increased p53 and GADD45alpha expression; the key regulators of the NER pathway and DNA repair. | Silybin | tumor protein p53 | Homo sapiens |
| 3 | Moreover, in the presence of pifithrin-alpha, an inhibitor of p53, the DNA repair efficacy of silibinin was compromised associated with a reduction in XPA and GADD45alpha transcripts. | Silybin | tumor protein p53 | Homo sapiens |
| 4 | Together, these findings suggest that silibinin"s efficacy against UVB-induced photodamage is primarily by inhibiting NER and p53; and these findings further support silibinin"s usage as a potential inexpensive, effective, and non-toxic agent for skin cancer chemoprevention. | Silybin | tumor protein p53 | Homo sapiens |