Caffeine

tumor protein p53 ; Homo sapiens







73 Article(s)
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1 32062581 The dichotomous effects of caffeine on homologous recombination in mammalian cells. 2020 Apr 2
2 33015038 Caffeine Targets SIRT3 to Enhance SOD2 Activity in Mitochondria. 2020 1
3 33177647 Coffee decoction enhances tamoxifen proapoptotic activity on MCF-7 cells. 2020 Nov 11 1
4 31168028 Polyhexamethylene guanidine phosphate-induced ROS-mediated DNA damage caused cell cycle arrest and apoptosis in lung epithelial cells. 2019 1
5 30050935 Caffeine Sensitizes U87-MG Human Glioblastoma Cells to Temozolomide through Mitotic Catastrophe by Impeding G2 Arrest. 2018 2
6 30197757 Zac1 regulates IL-11 expression in osteoarthritis. 2018 Aug 21 1
7 26965143 Constitutive Activation of DNA Damage Checkpoint Signaling Contributes to Mutant p53 Accumulation via Modulation of p53 Ubiquitination. 2016 May 2
8 26521794 Caffeine Suppresses Apoptosis of Bladder Cancer RT4 Cells in Response to Ionizing Radiation by Inhibiting Ataxia Telangiectasia Mutated-Chk2-p53 Axis. 2015 Nov 5 4
9 24333670 Caffeine induces tumor cytotoxicity via the regulation of alternative splicing in subsets of cancer-associated genes. 2014 Feb 6
10 24444450 Acrylamide-induced apoptosis in rat primary astrocytes and human astrocytoma cell lines. 2014 Jun 1
11 24595168 Caffeine mediates sustained inactivation of breast cancer-associated myofibroblasts via up-regulation of tumor suppressor genes. 2014 1
12 25482947 mTOR inhibitors blunt the p53 response to nucleolar stress by regulating RPL11 and MDM2 levels. 2014 1
13 21964066 The p53-p21WAF1 checkpoint pathway plays a protective role in preventing DNA rereplication induced by abrogation of FOXF1 function. 2012 Jan 1
14 22993301 Caffeine induces apoptosis of osteosarcoma cells by inhibiting AKT/mTOR/S6K, NF-κB and MAPK pathways. 2012 Sep 1
15 21081844 Caffeine induces apoptosis by enhancement of autophagy via PI3K/Akt/mTOR/p70S6K inhibition. 2011 Feb 1
16 20103602 Caffeine confers radiosensitization of PTEN-deficient malignant glioma cells by enhancing ionizing radiation-induced G1 arrest and negatively regulating Akt phosphorylation. 2010 Feb 2
17 20413215 Gambogic acid triggers DNA damage signaling that induces p53/p21(Waf1/CIP1) activation through the ATR-Chk1 pathway. 2010 Oct 1 1
18 19536869 Shallot and licorice constituent isoliquiritigenin arrests cell cycle progression and induces apoptosis through the induction of ATM/p53 and initiation of the mitochondrial system in human cervical carcinoma HeLa cells. 2009 Jul 1
19 19705844 Tricetin, a dietary flavonoid, inhibits proliferation of human breast adenocarcinoma mcf-7 cells by blocking cell cycle progression and inducing apoptosis. 2009 Sep 23 1
20 19735649 Oxaliplatin-induced gamma-H2AX activation via both p53-dependent and -independent pathways but is not associated with cell cycle arrest in human colorectal cancer cells. 2009 Dec 10 1
21 18223691 p21(WAF1/CIP1) induction by 5-azacytosine nucleosides requires DNA damage. 2008 Jun 5 2
22 18440285 Sustained activation of p53 in confluent nucleotide excision repair-deficient cells resistant to ultraviolet-induced apoptosis. 2008 Jun 1 2
23 18507003 Identification of novel genes involved in the synergistic antitumor effect of caffeine in osteosarcoma cells using cDNA macroarray. 2008 Mar-Apr 1
24 18511169 Kotomolide A arrests cell cycle progression and induces apoptosis through the induction of ATM/p53 and the initiation of mitochondrial system in human non-small cell lung cancer A549 cells. 2008 Jul 1
25 17096346 Selective cytotoxicity of benzyl isothiocyanate in the proliferating fibroblastoid cells. 2007 Feb 1 1
26 17292432 Phosphorylation of p53 at serine 15 in A549 pulmonary epithelial cells exposed to vanadate: involvement of ATM pathway. 2007 Apr 1 1
27 17510082 Aspirin blocks proliferation in colon cells by inducing a G1 arrest and apoptosis through activation of the checkpoint kinase ATM. 2007 Oct 1
28 17638302 Neuroprotective effects of caffeine against complex I inhibition-induced apoptosis are mediated by inhibition of the Atm/p53/E2F-1 path in cerebellar granule neurons. 2007 Nov 1 2
29 17704360 DNA repair after irradiation in glioma cells and normal human astrocytes. 2007 Oct 1
30 17727682 Soy-derived isoflavones inhibit the growth of adult T-cell leukemia cells in vitro and in vivo. 2007 Nov 1
31 18088187 p53-dependent Chk1 phosphorylation is required for maintenance of prolonged G2 Arrest. 2007 Dec 2
32 16397265 The interaction between two radiosensitizers: 5-iododeoxyuridine and caffeine. 2006 Jan 1 4
33 16489026 Stalled replication induces p53 accumulation through distinct mechanisms from DNA damage checkpoint pathways. 2006 Feb 15 1
34 15650224 Human herpesvirus 6B induces cell cycle arrest concomitant with p53 phosphorylation and accumulation in T cells. 2005 Feb 1
35 16024610 Nitric oxide-induced apoptosis in lymphoblastoid and fibroblast cells dependent on the phosphorylation and activation of p53. 2005 Jul 15 1
36 14743382 Cell cycle checkpoints and their impact on anticancer therapeutic strategies. 2004 Feb 1 1
37 14751246 Conflicting effects of caffeine on apoptosis and clonogenic survival of human K1 thyroid carcinoma cell lines with different p53 status after exposure to cisplatin or UVc irradiation. 2004 Feb 20 1
38 14757171 Genistein arrests hepatoma cells at G2/M phase: involvement of ATM activation and upregulation of p21waf1/cip1 and Wee1. 2004 Feb 15 1
39 15169897 Activation of a DNA damage checkpoint response in a TAF1-defective cell line. 2004 Jun 1
40 15466201 Apoptosis resistance of MCF-7 breast carcinoma cells to ionizing radiation is independent of p53 and cell cycle control but caused by the lack of caspase-3 and a caffeine-inhibitable event. 2004 Oct 1 1
41 12646262 Loss of p53 induces M-phase retardation following G2 DNA damage checkpoint abrogation. 2003 Apr 1 2
42 12719724 Nitric oxide promotes p53 nuclear retention and sensitizes neuroblastoma cells to apoptosis by ionizing radiation. 2003 Apr 2
43 12807744 Hypoxia induces p53 through a pathway distinct from most DNA-damaging and stress-inducing agents. 2003 Jul 3
44 12811820 Caffeine induces G2/M arrest and apoptosis via a novel p53-dependent pathway in NB4 promyelocytic leukemia cells. 2003 Aug 8
45 12874009 G2 arrest in response to topoisomerase II inhibitors: the role of p53. 2003 Jul 15 1
46 12894503 Inhibition of cisplatin-induced ATR activity and enhanced sensitivity to cisplatin. 2003 May-Jun 1
47 12902982 Myc and E2F1 induce p53 through p14ARF-independent mechanisms in human fibroblasts. 2003 Aug 7 1
48 12907610 Induction of apoptosis by caffeine is mediated by the p53, Bax, and caspase 3 pathways. 2003 Aug 1 1
49 14599774 Inhibition of DNA repair by Pentoxifylline and related methylxanthine derivatives. 2003 Nov 15 1
50 14643431 Caffeine and human DNA metabolism: the magic and the mystery. 2003 Nov 27 1