Title : The dichotomous effects of caffeine on homologous recombination in mammalian cells.

Pub. Date : 2020 Apr

PMID : 32062581






2 Functional Relationships(s)
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1 Caffeine exposure also induced a strong DDR along with subsequent activation of wildtype p53 protein. Caffeine tumor protein p53 Homo sapiens
2 Thus, prolonged caffeine exposure stalls the cell cycle, induces a p53-mediated apoptotic response and a down-regulation of critical HR proteins, and for reasons discussed, stimulates early steps of HR, but not the formation of complete recombination products. Caffeine tumor protein p53 Homo sapiens