Pub. Date : 2014 Feb
PMID : 24333670
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The detailed mechanisms of caffeine in tumor suppression via tumor suppressor protein p53 remain unclear. | Caffeine | tumor protein p53 | Homo sapiens |
| 2 | In this study, we investigated how caffeine modulated cell cycle arrest and apoptosis via the expression of various alternatively spliced p53 isoforms. | Caffeine | tumor protein p53 | Homo sapiens |
| 3 | Caffeine reduced p53alpha expression and induced the expression of p53beta, which contains an alternatively spliced p53 C-terminus. | Caffeine | tumor protein p53 | Homo sapiens |
| 4 | Caffeine reduced p53alpha expression and induced the expression of p53beta, which contains an alternatively spliced p53 C-terminus. | Caffeine | tumor protein p53 | Homo sapiens |
| 5 | Serine/arginine-rich splicing factor 3 was a promising candidate for the serine/arginine-rich splicing factors responsible for the alternative splicing of p53 in response to caffeine treatment. | Caffeine | tumor protein p53 | Homo sapiens |
| 6 | In addition to p53-dependent functions, multiple target genes of serine/arginine-rich splicing factor 3 suggest that caffeine can regulate epithelial-mesenchymal-transition and hypoxic conditions to inhibit the survival of tumor cells. | Caffeine | tumor protein p53 | Homo sapiens |