Hexosamines

O-linked N-acetylglucosamine (GlcNAc) transferase ; Homo sapiens







64 Article(s)
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1 33098688 A missense mutation in a patient with developmental delay affects the activity and structure of the hexosamine biosynthetic pathway enzyme AGX1. 2021 Jan 1
2 34445596 Hexosamine Biosynthetic Pathway-Derived O-GlcNAcylation Is Critical for RANKL-Mediated Osteoclast Differentiation. 2021 Aug 18 2
3 32628333 ELT-2 promotes O-GlcNAc transferase OGT-1 expression to modulate Caenorhabditis elegans lifespan. 2020 Jul 6 1
4 33329753 O-GlcNAc: Regulator of Signaling and Epigenetics Linked to X-linked Intellectual Disability. 2020 1
5 30818760 Cell Metabolism Control Through O-GlcNAcylation of STAT5: A Full or Empty Fuel Tank Makes a Big Difference for Cancer Cell Growth and Survival. 2019 Feb 27 1
6 29352075 O-Linked β-N-acetylglucosamine (O-GlcNAc) modification: a new pathway to decode pathogenesis of diabetic retinopathy. 2018 Jan 31 1
7 29706631 O-GlcNAc elevation through activation of the hexosamine biosynthetic pathway enhances cancer cell chemoresistance. 2018 May 1 1
8 30237786 Real Talk: The Inter-play Between the mTOR, AMPK, and Hexosamine Biosynthetic Pathways in Cell Signaling. 2018 2
9 30356686 Cross-Dysregulation of O-GlcNAcylation and PI3K/AKT/mTOR Axis in Human Chronic Diseases. 2018 2
10 30538676 FGF23 Induction of O-Linked N-Acetylglucosamine Regulates IL-6 Secretion in Human Bronchial Epithelial Cells. 2018 1
11 28008135 GFAT1 phosphorylation by AMPK promotes VEGF-induced angiogenesis. 2017 Mar 7 1
12 26923859 Elevated glucose levels impair the WNT/β-catenin pathway via the activation of the hexosamine biosynthesis pathway in endometrial cancer. 2016 May 1
13 27114449 A Novel Quantitative Mass Spectrometry Platform for Determining Protein O-GlcNAcylation Dynamics. 2016 Jul 1
14 27252680 Silencing the Nucleocytoplasmic O-GlcNAc Transferase Reduces Proliferation, Adhesion, and Migration of Cancer and Fetal Human Colon Cell Lines. 2016 2
15 27703839 Formal modeling and analysis of the hexosamine biosynthetic pathway: role of O-linked N-acetylglucosamine transferase in oncogenesis and cancer progression. 2016 1
16 25627821 High glucose induces mitochondrial dysfunction independently of protein O-GlcNAcylation. 2015 Apr 1 1
17 25663381 O-linked β-N-acetylglucosamine transferase directs cell proliferation in idiopathic pulmonary arterial hypertension. 2015 Apr 7 2
18 26499076 O-Linked N-acetylglucosaminylation of Sp1 interferes with Sp1 activation of glycolytic genes. 2015 Dec 4-11 1
19 24524620 Functional O-GlcNAc modifications: implications in molecular regulation and pathophysiology. 2014 Mar-Apr 2
20 24550151 The role of O-GlcNAc signaling in the pathogenesis of diabetic retinopathy. 2014 Apr 1
21 24630721 Spliced X-box binding protein 1 couples the unfolded protein response to hexosamine biosynthetic pathway. 2014 Mar 13 3
22 24692660 AMPK regulates histone H2B O-GlcNAcylation. 2014 May 1
23 24759912 O-GlcNAc and neurodegeneration: biochemical mechanisms and potential roles in Alzheimer's disease and beyond. 2014 Oct 7 1
24 24921011 Extracellular O-linked β-N-acetylglucosamine: Its biology and relationship to human disease. 2014 May 26 1
25 25148700 The mitochondrial O-linked N-acetylglucosamine transferase (mOGT) in the diabetic patient could be the initial trigger to develop Alzheimer disease. 2014 Oct 2
26 25250015 O-GlcNAcylation and Metabolic Reprograming in Cancer. 2014 2
27 25628602 O-GlcNAcylation Links ChREBP and FXR to Glucose-Sensing. 2014 2
28 27896086 Differential hexosamine biosynthetic pathway gene expression with type 2 diabetes. 2014 1
29 22985933 Post-translational protein modification by O-linked N-acetyl-glucosamine: its role in mediating the adverse effects of diabetes on the heart. 2013 Mar 28 2
30 23301498 Proteome wide purification and identification of O-GlcNAc-modified proteins using click chemistry and mass spectrometry. 2013 Feb 1 1
31 23720054 O-GlcNAc transferase integrates metabolic pathways to regulate the stability of c-MYC in human prostate cancer cells. 2013 Aug 15 2
32 23836420 O-GlcNAc in cancer biology. 2013 Oct 1
33 23935944 O-GlcNAcylation-inducing treatments inhibit estrogen receptor α expression and confer resistance to 4-OH-tamoxifen in human breast cancer-derived MCF-7 cells. 2013 2
34 24129563 Triptolide-induced cell death in pancreatic cancer is mediated by O-GlcNAc modification of transcription factor Sp1. 2013 Nov 22 1
35 21374590 Suppression of Glutamine:fructose-6-phosphate amidotransferase-1 inhibits adipogenesis in 3T3-L1 adipocytes. 2012 Jan 1
36 22275356 Critical role of O-Linked β-N-acetylglucosamine transferase in prostate cancer invasion, angiogenesis, and metastasis. 2012 Mar 30 1
37 22692202 Metabolism of vertebrate amino sugars with N-glycolyl groups: intracellular β-O-linked N-glycolylglucosamine (GlcNGc), UDP-GlcNGc, and the biochemical and structural rationale for the substrate tolerance of β-O-linked β-N-acetylglucosaminidase. 2012 Aug 17 1
38 23027940 Modification of RelA by O-linked N-acetylglucosamine links glucose metabolism to NF-κB acetylation and transcription. 2012 Oct 16 1
39 23066116 Exploring leukocyte O-GlcNAcylation as a novel diagnostic tool for the earlier detection of type 2 diabetes mellitus. 2012 Dec 1
40 21697645 Glucosamine induces cell death via proteasome inhibition in human ALVA41 prostate cancer cell. 2011 Sep 30 1
41 21807949 A lipid-droplet-targeted O-GlcNAcase isoform is a key regulator of the proteasome. 2011 Aug 15 1
42 22158438 O-linked-N-acetylglucosamine on extracellular protein domains mediates epithelial cell-matrix interactions. 2011 Dec 13 2
43 19647043 The hexosamine signaling pathway: O-GlcNAc cycling in feast or famine. 2010 Feb 1
44 19799964 Hexosamine flux, the O-GlcNAc modification, and the development of insulin resistance in adipocytes. 2010 Apr 29 3
45 20043149 O-GlcNAc modification of proteins affects volume regulation in Jurkat cells. 2010 Jul 1
46 20190804 Nutrient sensor O-GlcNAc transferase regulates breast cancer tumorigenesis through targeting of the oncogenic transcription factor FoxM1. 2010 May 13 1
47 20466550 O-GlcNAc signaling: a metabolic link between diabetes and cancer? 2010 Oct 1
48 20488252 O-GlcNAc cycling: emerging roles in development and epigenetics. 2010 Aug 1
49 20668475 Aberrant O-GlcNAcylation characterizes chronic lymphocytic leukemia. 2010 Sep 1
50 19073609 Up-regulation of O-GlcNAc transferase with glucose deprivation in HepG2 cells is mediated by decreased hexosamine pathway flux. 2009 Feb 6 1