| 1 |
35187492 | ATP Synthase K+- and H+-fluxes Drive ATP Synthesis and Enable Mitochondrial K+-"Uniporter" Function: II. Ion and ATP Synthase Flux Regulation. | 2022 |
1 |
| 2 |
35332309 | BH3 mimetic drugs cooperate with Temozolomide, JQ1 and inducers of ferroptosis in killing glioblastoma multiforme cells. | 2022 Mar 24 |
1 |
| 3 |
35473984 | Increased apoptotic sensitivity of glioblastoma enables therapeutic targeting by BH3-mimetics. | 2022 Apr 26 |
1 |
| 4 |
33241675 | Inhibition of the anti-apoptotic protein MCL-1 severely suppresses human hematopoiesis | 2021 Dec 1 |
1 |
| 5 |
33253879 | Interdiction at a protein-protein interface: MCL-1 inhibitors for oncology. | 2021 Jan 15 |
1 |
| 6 |
33690800 | Cytokine-like protein 1-induced survival of monocytes suggests a combined strategy targeting MCL1 and MAPK in CMML. | 2021 Jun 17 |
1 |
| 7 |
33785871 | Breast cancer dependence on MCL-1 is due to its canonical anti-apoptotic function. | 2021 Sep |
1 |
| 8 |
33806619 | Stroma-Mediated Resistance to S63845 and Venetoclax through MCL-1 and BCL-2 Expression Changes Induced by miR-193b-3p and miR-21-5p Dysregulation in Multiple Myeloma. | 2021 Mar 4 |
1 |
| 9 |
34065859 | Unmasking BCL-2 Addiction in Synovial Sarcoma by Overcoming Low NOXA. | 2021 May 12 |
1 |
| 10 |
34088830 | Therapeutic Synergy in Esophageal Cancer and Mesothelioma Is Predicted by Dynamic BH3 Profiling. | 2021 Aug |
1 |
| 11 |
34257082 | Cell Line-Specific Network Models of ER+ Breast Cancer Identify Potential PI3Kα Inhibitor Resistance Mechanisms and Drug Combinations. | 2021 Sep 1 |
1 |
| 12 |
34320168 | BCL2 and MCL1 inhibitors for hematologic malignancies. | 2021 Sep 30 |
1 |
| 13 |
34349655 | Mcl-1 Inhibition: Managing Malignancy in Multiple Myeloma. | 2021 |
1 |
| 14 |
34385422 | Constitutive BAK/MCL1 complexes predict paclitaxel and S63845 sensitivity of ovarian cancer. | 2021 Aug 12 |
1 |
| 15 |
34478517 | Heterogeneous modulation of Bcl-2 family members and drug efflux mediate MCL-1 inhibitor resistance in multiple myeloma. | 2021 Oct 26 |
1 |
| 16 |
34568318 | MCL-1 Inhibition Overcomes Anti-apoptotic Adaptation to Targeted Therapies in B-Cell Precursor Acute Lymphoblastic Leukemia. | 2021 |
1 |
| 17 |
34781947 | Functional apoptosis profiling identifies MCL-1 and BCL-xL as prognostic markers and therapeutic targets in advanced thymomas and thymic carcinomas. | 2021 Nov 16 |
2 |
| 18 |
31332296 | BH3 profiling discriminates on-target small molecule BH3 mimetics from putative mimetics. | 2020 Mar |
1 |
| 19 |
31388792 | A phase I study of AT-101, a BH3 mimetic, in combination with paclitaxel and carboplatin in solid tumors. | 2020 Jun |
1 |
| 20 |
32111816 | MCL1 binding to the reverse BH3 motif of P18INK4C couples cell survival to cell proliferation. | 2020 Feb 28 |
1 |
| 21 |
32183335 | Restoring Apoptosis with BH3 Mimetics in Mature B-Cell Malignancies. | 2020 Mar 14 |
1 |
| 22 |
32203216 | A direct comparison of selective BH3-mimetics reveals BCL-XL, BCL-2 and MCL-1 as promising therapeutic targets in neuroblastoma. | 2020 May |
3 |
| 23 |
32457483 | BH3 mimetics selectively eliminate chemotherapy-induced senescent cells and improve response in TP53 wild-type breast cancer. | 2020 Nov |
1 |
| 24 |
32484436 | MARCH5 mediates NOXA-dependent MCL1 degradation driven by kinase inhibitors and integrated stress response activation. | 2020 Jun 2 |
1 |
| 25 |
32659848 | Pairing MCL-1 inhibition with venetoclax improves therapeutic efficiency of BH3-mimetics in AML. | 2020 Nov |
1 |
| 26 |
32717194 | Mcl-1-mediated mitochondrial fission protects against stress but impairs cardiac adaptation to exercise. | 2020 Sep |
1 |
| 27 |
32801295 | Sequential combinations of chemotherapeutic agents with BH3 mimetics to treat rhabdomyosarcoma and avoid resistance. | 2020 Aug 15 |
1 |
| 28 |
33146015 | Computational Design of BH3-Mimetic Peptide Inhibitors That Can Bind Specifically to Mcl-1 or Bcl-XL: Role of Non-Hot Spot Residues. | 2020 Nov 17 |
1 |
| 29 |
33198338 | BH3 Mimetics for the Treatment of B-Cell Malignancies-Insights and Lessons from the Clinic. | 2020 Nov 12 |
1 |
| 30 |
33217342 | Reduced Mitochondrial Apoptotic Priming Drives Resistance to BH3 Mimetics in Acute Myeloid Leukemia. | 2020 Dec 14 |
1 |
| 31 |
29924730 | Selective BH3-mimetics targeting BCL-2, BCL-XL or MCL-1 induce severe mitochondrial perturbations. | 2019 Jan 28 |
2 |
| 32 |
30185825 | BH3-only proteins are dispensable for apoptosis induced by pharmacological inhibition of both MCL-1 and BCL-XL. | 2019 Jun |
1 |
| 33 |
30214012 | Combining BH3-mimetics to target both BCL-2 and MCL1 has potent activity in pre-clinical models of acute myeloid leukemia. | 2019 Apr |
1 |
| 34 |
30467206 | Targeting intermediary metabolism enhances the efficacy of BH3 mimetic therapy in hematologic malignancies. | 2019 May |
1 |
| 35 |
30470795 | Impact of elevated anti-apoptotic MCL-1 and BCL-2 on the development and treatment of MLL-AF9 AML in mice. | 2019 Jul |
2 |
| 36 |
30498064 | Biomarker-driven strategy for MCL1 inhibition in T-cell lymphomas. | 2019 Feb 7 |
1 |
| 37 |
30649895 | Alveolar Macrophage Apoptosis-associated Bacterial Killing Helps Prevent Murine Pneumonia. | 2019 Jul 1 |
1 |
| 38 |
31228231 | Targeting prosurvival BCL2 signaling through Akt blockade sensitizes castration-resistant prostate cancer cells to enzalutamide. | 2019 Aug |
1 |
| 39 |
31235261 | Discovery of novel biaryl sulfonamide based Mcl-1 inhibitors. | 2019 Aug 15 |
1 |
| 40 |
31341643 | DRP-1 functions independently of mitochondrial structural perturbations to facilitate BH3 mimetic-mediated apoptosis. | 2019 |
1 |
| 41 |
31421829 | A peptide containing Noxa mitochondrial-targeting domain induces cell death via mitochondrial and endoplasmic reticulum disruption. | 2019 Oct 8 |
1 |
| 42 |
31467488 | The deubiquitinating enzyme OTUD1 antagonizes BH3-mimetic inhibitor induced cell death through regulating the stability of the MCL1 protein. | 2019 |
2 |
| 43 |
33763603 | Photocatalytic proximity labelling of MCL-1 by a BH3 ligand. | 2019 Nov 21 |
1 |
| 44 |
28947136 | BCL-xL-selective BH3 mimetic sensitizes rhabdomyosarcoma cells to chemotherapeutics by activation of the mitochondrial pathway of apoptosis. | 2018 Jan 1 |
1 |
| 45 |
29099483 | The BCL-2 arbiters of apoptosis and their growing role as cancer targets. | 2018 Jan |
1 |
| 46 |
29188305 | Synergistic cytotoxicity of a prostate cancer-specific immunotoxin in combination with the BH3 mimetic ABT-737. | 2018 Mar |
1 |
| 47 |
29298347 | Predicting effective pro-apoptotic anti-leukaemic drug combinations using co-operative dynamic BH3 profiling. | 2018 |
3 |
| 48 |
29394130 | DZNep represses Bcl-2 expression and modulates apoptosis sensitivity in response to Nutlin-3a. | 2018 Jun 3 |
1 |
| 49 |
29499131 | Dynamic Regulation of Long-Chain Fatty Acid Oxidation by a Noncanonical Interaction between the MCL-1 BH3 Helix and VLCAD. | 2018 Mar 1 |
3 |
| 50 |
29580266 | Synergistic anti-proliferative effects of combination of ABT-263 and MCL-1 selective inhibitor A-1210477 on cervical cancer cell lines. | 2018 Mar 27 |
1 |