Title : Discovery of novel biaryl sulfonamide based Mcl-1 inhibitors.

Pub. Date : 2019 Aug 15

PMID : 31235261






1 Functional Relationships(s)
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Protein Name
Organism
1 The crystal structure of the Mcl-1 bound ligand represents a unique binding mode to the BH3 binding pocket where binding affinity is achieved, in part, through a sulfonamide oxygen/Arg263 interaction. BH 3 MCL1 apoptosis regulator, BCL2 family member Homo sapiens