Title : MARCH5 mediates NOXA-dependent MCL1 degradation driven by kinase inhibitors and integrated stress response activation.

Pub. Date : 2020 Jun 2

PMID : 32484436






1 Functional Relationships(s)
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1 Therapies that enhance MARCH5-mediated MCL1 degradation markedly enhance apoptosis in response to a BH3 mimetic agent targeting BCLXL, which may provide for a broadly effective therapy in solid tumors. BH 3 MCL1 apoptosis regulator, BCL2 family member Homo sapiens