Mevalonic Acid

3-hydroxy-3-methylglutaryl-CoA reductase ; Rattus norvegicus







49 Article(s)
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1 32319638 MicroRNA‑125a‑mediated regulation of the mevalonate signaling pathway contributes to high glucose‑induced proliferation and migration of vascular smooth muscle cells. 2020 Jul 2
2 29568741 Alteration of Mevalonate Pathway in Rat Splenic Lymphocytes: Possible Role in Cytokines Secretion Regulated by L-Theanine. 2018 1
3 28864210 Inhibition of the mevalonate pathway by simvastatin interferes with mast cell degranulation by disrupting the interaction between Rab27a and double C2 alpha proteins. 2017 Nov 5 1
4 26986474 Rosuvastatin Treatment Affects Both Basal and Glucose-Induced Insulin Secretion in INS-1 832/13 Cells. 2016 1
5 27051663 Simvastatin Results in a Dose-Dependent Toxic Effect on Spiral Ganglion Neurons in an In Vitro Organotypic Culture Assay. 2016 1
6 27158912 Myrtenal alleviates hyperglycaemia, hyperlipidaemia and improves pancreatic insulin level in STZ-induced diabetic rats. 2016 Nov 1
7 21906051 Differential effects of atorvastatin treatment and withdrawal on pentylenetetrazol-induced seizures. 2011 Nov 1
8 19571257 Role of isoprenylation in simvastatin-induced inhibition of ovarian theca-interstitial growth in the rat. 2009 Nov 1
9 17303974 Statins ameliorate glomerular permeability changes in streptozotocin-induced diabetic rats. 2007 Jan-Feb 1
10 16872642 Fluvastatin stabilizes the blood-brain barrier in vitro by nitric oxide-dependent dephosphorylation of myosin light chains. 2006 Sep 1
11 14627708 Apomine, a novel hypocholesterolemic agent, accelerates degradation of 3-hydroxy-3-methylglutaryl-coenzyme A reductase and stimulates low density lipoprotein receptor activity. 2004 Feb 20 2
12 15134389 Effects of D-003, a mixture of high molecular weight aliphatic acids from sugar cane wax, on bones from ovariectomized rats. 2004 1
13 15364922 Inhibition of geranylgeranylation mediates the effects of 3-hydroxy-3-methylglutaryl (HMG)-CoA reductase inhibitors on microglia. 2004 Nov 12 1
14 12510809 The ability of statins to inhibit bone resorption is directly related to their inhibitory effect on HMG-CoA reductase activity. 2003 Jan 1
15 12518023 Apoptosis induced by clofibrate in Yoshida AH-130 hepatoma cells: role of HMG-CoA reductase. 2003 Jan 1
16 12841361 Contribution of increased HMG-CoA reductase gene expression to hypercholesterolemia in experimental chronic renal failure. 2003 Apr 1
17 11275002 Effect of simvastatin on vascular smooth muscle responsiveness: involvement of Ca(2+) homeostasis. 2001 Mar 1
18 10743676 Effect of simvastatin therapy on blood and tissue ATP levels and erythrocyte membrane lipid composition. 2000 Feb 1
19 10751437 Geranylgeranyl-pyrophosphate, an isoprenoid of mevalonate cascade, is a critical compound for rat primary cultured cortical neurons to protect the cell death induced by 3-hydroxy-3-methylglutaryl-CoA reductase inhibition. 2000 Apr 15 2
20 10753223 Inhibition of N-methyl-N-nitrosourea- and 7,12-dimethylbenz[a] anthracene-induced rat mammary tumorigenesis by dietary cholesterol is independent of Ha-Ras mutations. 2000 Apr 1
21 10946069 HMG CoA reductase inhibition reduces sarcolemmal Na(+)-K(+) pump density. 2000 Aug 1
22 10412745 Effect of simvastatin on proliferative nephritis and cell-cycle protein expression. 1999 Jul 1
23 9221828 Inhibition of cholesterol synthesis by squalene synthase inhibitors does not induce myotoxicity in vitro. 1997 Jul 2
24 9288773 Regulation of mevalonate synthesis in rat mammary glands by dietary n-3 and n-6 polyunsaturated fatty acids. 1997 Sep 1 1
25 8645011 Farnesol is not the nonsterol regulator mediating degradation of HMG-CoA reductase in rat liver. 1996 Apr 15 1
26 7974251 Prevention of fluvastatin-induced toxicity, mortality, and cardiac myopathy in pregnant rats by mevalonic acid supplementation. 1994 Jul 1
27 8276863 Mevalonic acid-dependent degradation of 3-hydroxy-3-methylglutaryl-coenzyme A reductase in vivo and in vitro. 1994 Jan 7 2
28 8446927 HMG-CoA reductase mRNA in the post-implantation rat embryo studied by in situ hybridization. 1993 Feb 2
29 8482726 Mevalonate controls cytoskeleton organization and cell morphology in thyroid epithelial cells. 1993 May 1
30 1399833 Developmental expression of multiple forms of 3-hydroxy-3-methylglutaryl coenzyme A reductase mRNA in rat testes. 1992 Jul-Aug 1
31 1827487 Role of isoprenoid metabolism in IgE receptor-mediated signal transduction. 1991 May 15 1
32 1846516 Possible involvement of 3-hydroxymethylglutaryl-CoA reductase in determining the side-chain length of ubiquinone in rat heart. 1991 Jan 1
33 2247467 Lovastatin decreases coenzyme Q levels in rats. 1990 Nov 1
34 2313206 Regulation of bile acid synthesis. IV. Interrelationship between cholesterol and bile acid biosynthesis pathways. 1990 Jan 1
35 2362431 Regulation of 3-hydroxyl-3-methylglutaryl-coenzyme A reductase activity in rat uterine tissues. 1990 May 1
36 2836685 Short-term changes in hepatic HMG-CoA reductase in rats fed diets containing cholesterol or oat bran. 1987 Dec 2
37 2892200 Regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase: search for the enzyme's repressor derived from mevalonate. 1987 Sep 22 3
38 3742535 Regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase by mevalonate and cholesterol in isolated rat hepatocytes during perinatal development. 1986 1
39 4019479 Mevalonate utilization in Pseudomonas sp. M. Purification and characterization of an inducible 3-hydroxy-3-methylglutaryl coenzyme A reductase. 1985 Aug 5 1
40 6594693 In vivo modulation of rat liver 3-hydroxy-3-methylglutaryl-coenzyme A reductase, reductase kinase, and reductase kinase kinase by mevalonolactone. 1984 Dec 1
41 6286363 Modulation of rat liver 3-hydroxy-3-methylglutaryl-CoA reductase activity by reversible phosphorylation. 1982 Aug 1
42 6948302 In vivo regulation of rat liver 3-hydroxy-3-methylglutaryl-coenzyme A reductase: immunotitration of the enzyme after short-term mevalonate or cholesterol feeding. 1982 Jan 1
43 6113851 [Activities of 3-hydroxy-3-methylglutaryl-CoA reductase and acetyl-CoA carboxylase and rate of biosynthesis of mevalonic acid, squalene, sterols and fatty acids from [1-14C]acetyl-CoA and [2-14C]malonyl-CoA in rat liver: changes induced by daily rhythm]. 1981 Jan 2
44 7193053 Evidence that physiologic levels of circulating estrogens and neonatal sex-imprinting modify postpubertal hepatic microsomal 3-hydroxy-3-methylglutaryl coenzyme A reductase activity. 1980 Dec 1 1
45 7438103 Inhibition of 3-hydroxy-3-methylglutaryl coenzyme A reductase activity in Morris hepatoma 7800 after intravenous injection of mevalonic acid. 1980 Dec 3
46 291971 Characterization and regulation of reductase kinase, a protein kinase that modulates the enzymic activity of 3-hydroxy-3-methylglutaryl-coenzyme A reductase. 1979 Sep 1
47 687657 On the mechanism for the regulation of 3-hydroxy-3-methylglutaryl-coenzyme A reductase, of cholesterol 7alpha-hydroxylase and of acyl-coenzyme A:cholesterol acyltransferase by free cholesterol. 1978 Jul 25 3
48 187533 [Studies on the regulatory factors of 3-hydroxy-3-methylglutaryl CoA reductase (HMG CoA reductase) activity]. 1976 Jul 1
49 1066664 Evidence for regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase activity and cholesterol synthesis in nonhepatic tissues of rat. 1976 Aug 1