Title : Inhibition of N-methyl-N-nitrosourea- and 7,12-dimethylbenz[a] anthracene-induced rat mammary tumorigenesis by dietary cholesterol is independent of Ha-Ras mutations.

Pub. Date : 2000 Apr

PMID : 10753223






1 Functional Relationships(s)
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1 Uptake of serum low density lipoprotein cholesterol by tissues leads to down-regulation of 3-hydroxy-3-methylglutaryl-CoA (HMG-CoA) reductase, the rate limiting enzyme in cholesterol biosynthesis that catalyzes the formation of mevalonate. Mevalonic Acid 3-hydroxy-3-methylglutaryl-CoA reductase Rattus norvegicus