| 1 |
33188300 | Biallelic variants in HPDL, encoding 4-hydroxyphenylpyruvate dioxygenase-like protein, lead to an infantile neurodegenerative condition. | 2021 Mar |
1 |
| 2 |
33365261 | High-throughput quantification of ochronotic pigment formation in Escherichia coli to evaluate the potency of human 4-hydroxyphenylpyruvate dioxygenase inhibitors in multi-well format. | 2021 |
5 |
| 3 |
34433044 | Loss of tyrosine catabolic enzyme HPD promotes glutamine anaplerosis through mTOR signaling in liver cancer. | 2021 Aug 24 |
5 |
| 4 |
34485014 | Vitiligo, alkaptonuria, and nitisinone-A report of three families and review of the literature. | 2021 Sep |
1 |
| 5 |
32109208 | Variant analysis of HPD genes from two families showing elevated tyrosine upon newborn screening by tandem mass spectrometry (MS/MS). | 2020 Apr 28 |
1 |
| 6 |
32750420 | Identification of key residues determining the binding specificity of human 4-hydroxyphenylpyruvate dioxygenase. | 2020 Nov 1 |
2 |
| 7 |
32756361 | Based on the Virtual Screening of Multiple Pharmacophores, Docking and Molecular Dynamics Simulation Approaches toward the Discovery of Novel HPPD Inhibitors. | 2020 Aug 3 |
2 |
| 8 |
32891822 | Tyrosine metabolic enzyme HPD is decreased and predicts unfavorable outcomes in hepatocellular carcinoma. | 2020 Nov |
1 |
| 9 |
30684868 | Hydrophobicity-oriented drug design (HODD) of new human 4-hydroxyphenylpyruvate dioxygenase inhibitors. | 2019 Mar 15 |
2 |
| 10 |
31277952 | HPD overexpression predicts poor prognosis in breast cancer. | 2019 Sep |
2 |
| 11 |
31285420 | 4-hydroxyphenylpyruvate dioxygenase promotes lung cancer growth via pentose phosphate pathway (PPP) flux mediated by LKB1-AMPK/HDAC10/G6PD axis. | 2019 Jul 8 |
1 |
| 12 |
31537781 | HPD degradation regulated by the TTC36-STK33-PELI1 signaling axis induces tyrosinemia and neurological damage. | 2019 Sep 19 |
2 |
| 13 |
31578365 | A robust bacterial assay for high-throughput screening of human 4-hydroxyphenylpyruvate dioxygenase inhibitors. | 2019 Oct 2 |
2 |
| 14 |
28128559 | 4-Hydroxyphenylpyruvate Dioxygenase and Its Inhibition in Plants and Animals: Small Molecules as Herbicides and Agents for the Treatment of Human Inherited Diseases. | 2017 May 25 |
1 |
| 15 |
28637410 | New Research for Quinazoline-2,4-diones as HPPD Inhibitors Based on 2D-MLR and 3D-QSAR Models. | 2017 |
2 |
| 16 |
26226126 | Hawkinsinuria in two unrelated Greek newborns: identification of a novel variant, biochemical findings and treatment. | 2016 Jan |
2 |
| 17 |
25590863 | Synthesis and bioevaluation of pyrazole-benzimidazolone hybrids as novel human 4-Hydroxyphenylpyruvate dioxygenase inhibitors. | 2015 Mar 6 |
2 |
| 18 |
26291655 | The Inhibitory Activity of Plants from Central Argentina on p-Hydroxyphenylpyruvate Dioxygenase. Isolation and Mechanism of Inhibition of a Flavanone from Flourensia oolepis. | 2015 Oct |
1 |
| 19 |
24952314 | Urine homogentisic acid and tyrosine: simultaneous analysis by liquid chromatography tandem mass spectrometry. | 2014 Jul 15 |
1 |
| 20 |
25182962 | Pyrazolone-quinazolone hybrids: a novel class of human 4-hydroxyphenylpyruvate dioxygenase inhibitors. | 2014 Oct 1 |
2 |
| 21 |
25266991 | The role of nitisinone in tyrosine pathway disorders. | 2014 Nov |
2 |
| 22 |
23402215 | A review of the mode of toxicity and relevance to humans of the triketone herbicide 2-(4-methylsulfonyl-2-nitrobenzoyl)-1,3-cyclohexanedione. | 2013 Mar |
5 |
| 23 |
23950902 | The interactions in the carboxyl terminus of human 4-hydroxyphenylpyruvate dioxygenase are critical to mediate the conformation of the final helix and the tail to shield the active site for catalysis. | 2013 |
2 |
| 24 |
23036342 | Tyrosinemia Type III detected via neonatal screening: management and outcome. | 2012 Nov |
2 |
| 25 |
19621095 | Inhibition of 4-hydroxyphenylpyruvate dioxygenase by 2-[2-nitro-4-(trifluoromethyl)benzoyl]-1,3-cyclohexanedione. | 2009 |
2 |
| 26 |
17152330 | [New drugs; nitisinone]. | 2006 Nov 18 |
1 |
| 27 |
15581571 | 4-Hydroxyphenylpyruvate dioxygenase. | 2005 Jan 1 |
2 |
| 28 |
16197918 | Spectroscopic and computational studies of NTBC bound to the non-heme iron enzyme (4-hydroxyphenyl)pyruvate dioxygenase: active site contributions to drug inhibition. | 2005 Dec 9 |
1 |
| 29 |
12127941 | Expression and post-translational modification of human 4-hydroxy-phenylpyruvate dioxygenase. | 2002 |
5 |
| 30 |
11916315 | Outcome of tyrosinaemia type III. | 2001 Dec |
1 |
| 31 |
10942115 | Mutations in the 4-hydroxyphenylpyruvate dioxygenase gene (HPD) in patients with tyrosinemia type III. | 2000 Jun |
2 |
| 32 |
11073718 | Mutations in the 4-hydroxyphenylpyruvic acid dioxygenase gene are responsible for tyrosinemia type III and hawkinsinuria. | 2000 Nov |
4 |
| 33 |
7851880 | Structure of the human 4-hydroxyphenylpyruvic acid dioxygenase gene (HPD). | 1994 Oct |
2 |
| 34 |
6611256 | Tyrosinemia and intractable seizures. | 1984 Aug |
1 |