Pub. Date : 2013 Mar
PMID : 23402215
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The key events in the MoA involve inhibition of the enzyme 4-hydroxyphenylpyruvate dioxygenase (HPPD), the second enzyme in the tyrosine catabolic pathway, resulting in excess plasma tyrosine (tyrosinemia). | Tyrosine | 4-hydroxyphenylpyruvate dioxygenase | Homo sapiens |
| 2 | The key events in the MoA involve inhibition of the enzyme 4-hydroxyphenylpyruvate dioxygenase (HPPD), the second enzyme in the tyrosine catabolic pathway, resulting in excess plasma tyrosine (tyrosinemia). | Tyrosine | 4-hydroxyphenylpyruvate dioxygenase | Homo sapiens |
| 3 | The key events in the MoA involve inhibition of the enzyme 4-hydroxyphenylpyruvate dioxygenase (HPPD), the second enzyme in the tyrosine catabolic pathway, resulting in excess plasma tyrosine (tyrosinemia). | Tyrosine | 4-hydroxyphenylpyruvate dioxygenase | Homo sapiens |
| 4 | The key events in the MoA involve inhibition of the enzyme 4-hydroxyphenylpyruvate dioxygenase (HPPD), the second enzyme in the tyrosine catabolic pathway, resulting in excess plasma tyrosine (tyrosinemia). | Tyrosine | 4-hydroxyphenylpyruvate dioxygenase | Homo sapiens |
| 5 | When HPPD is completely inhibited, the clearance of excess tyrosine is dependent upon catabolism by the first and rate-limiting enzyme in the catabolic pathway, tyrosine aminotransferase (TAT) and elimination of the products of this catabolism via the urine. | Tyrosine | 4-hydroxyphenylpyruvate dioxygenase | Homo sapiens |