| 1 |
34788822 | The dihydrofolate reductase 19-bp deletion modifies the beneficial effect of B-vitamin therapy in mild cognitive impairment: pooled study of two randomized placebo-controlled trials. | 2022 Mar 31 |
2 |
| 2 |
33315225 | Distal Regions Regulate Dihydrofolate Reductase-Ligand Interactions. | 2021 |
1 |
| 3 |
33724022 | FRAGSITE: A Fragment-Based Approach for Virtual Ligand Screening. | 2021 Apr 26 |
1 |
| 4 |
32752079 | In Silico Study Identified Methotrexate Analog as Potential Inhibitor of Drug Resistant Human Dihydrofolate Reductase for Cancer Therapeutics. | 2020 Jul 31 |
2 |
| 5 |
30508692 | Exploring PfDHFR reaction surface: A combined molecular dynamics and QM/MM analysis. | 2019 Mar |
1 |
| 6 |
30754680 | In Silico Study Probes Potential Inhibitors of Human Dihydrofolate Reductase for Cancer Therapeutics. | 2019 Feb 11 |
2 |
| 7 |
31401334 | Expression and Role of Methylenetetrahydrofolate Dehydrogenase 1 Like (MTHFD1L) in Bladder Cancer. | 2019 Nov |
2 |
| 8 |
32051770 | Loss of Hyperconjugative Effects Drives Hydride Transfer during Dihydrofolate Reductase Catalysis. | 2019 Nov 1 |
2 |
| 9 |
30019321 | Evolutionarily Related Dihydrofolate Reductases Perform Coequal Functions Yet Show Divergence in Their Trajectories. | 2018 Aug |
1 |
| 10 |
30398861 | Evolutionary Effects on Bound Substrate p Ka in Dihydrofolate Reductase. | 2018 Dec 5 |
2 |
| 11 |
28605138 | Pharmacoinformatic Study on the Selective Inhibition of the Protozoan Dihydrofolate Reductase Enzymes. | 2017 Nov |
2 |
| 12 |
27013776 | Down-regulation of dihydrofolate reductase inhibits the growth of endothelial EA.hy926 cell through induction of G1 cell cycle arrest via up-regulating p53 and p21(waf1/cip1) expression. | 2016 Mar |
1 |
| 13 |
26125523 | Structural Characterization of Dihydrofolate Reductase Complexes by Top-Down Ultraviolet Photodissociation Mass Spectrometry. | 2015 Jul 22 |
2 |
| 14 |
23267138 | Interaction between Gambogic acid and dihydrofolate reductase and synergistic lethal effects with methotrexate on hepatoma cells. | 2013 Jan |
1 |
| 15 |
23458706 | Further studies on the role of water in R67 dihydrofolate reductase. | 2013 Mar 26 |
2 |
| 16 |
23726796 | Overexpression of thymidylate synthetase confers an independent prognostic indicator in nasopharyngeal carcinoma. | 2013 Aug |
2 |
| 17 |
24053355 | First three-dimensional structure of Toxoplasma gondii thymidylate synthase-dihydrofolate reductase: insights for catalysis, interdomain interactions, and substrate channeling. | 2013 Oct 15 |
2 |
| 18 |
24122410 | Insight into the molecular mechanism about lowered dihydrofolate binding affinity to dihydrofolate reductase-like 1 (DHFRL1). | 2013 Dec |
6 |
| 19 |
22369433 | Weak interactions between folate and osmolytes in solution. | 2012 Mar 20 |
1 |
| 20 |
22734697 | Mechanism inspired development of rationally designed dihydrofolate reductase inhibitors as anticancer agents. | 2012 Jul 26 |
2 |
| 21 |
24300187 | Preparation and characterization of amino acids-based trimethoprim salts. | 2012 Feb 16 |
2 |
| 22 |
26596739 | Momentum Distribution as a Fingerprint of Quantum Delocalization in Enzymatic Reactions: Open-Chain Path-Integral Simulations of Model Systems and the Hydride Transfer in Dihydrofolate Reductase. | 2012 Apr 10 |
2 |
| 23 |
21876184 | The former annotated human pseudogene dihydrofolate reductase-like 1 (DHFRL1) is expressed and functional. | 2011 Sep 13 |
2 |
| 24 |
19697148 | In silico structure-based design of a novel class of potent and selective small peptide inhibitor of Mycobacterium tuberculosis Dihydrofolate reductase, a potential target for anti-TB drug discovery. | 2010 Aug |
1 |
| 25 |
21629435 | Dihydrofolate reductase gene variations in susceptibility to disease and treatment outcomes. | 2010 Dec |
2 |
| 26 |
18247058 | An insertion/deletion polymorphism of the dihydrofolate reductase (DHFR) gene is associated with serum and red blood cell folate concentrations in women. | 2008 Apr |
1 |
| 27 |
18804698 | Regulation of human dihydrofolate reductase activity and expression. | 2008 |
2 |
| 28 |
16969375 | Molecular genetic analysis of the human dihydrofolate reductase gene: relation with plasma total homocysteine, serum and red blood cell folate levels. | 2007 Jan |
1 |
| 29 |
17346178 | Dihydrofolate reductase as a target for chemotherapy in parasites. | 2007 |
1 |
| 30 |
17413111 | A functional 19-base pair deletion polymorphism of dihydrofolate reductase (DHFR) and risk of breast cancer in multivitamin users. | 2007 Apr |
3 |
| 31 |
16790925 | High-resolution structure of a plasmid-encoded dihydrofolate reductase: pentagonal network of water molecules in the D2-symmetric active site. | 2006 Jul |
1 |
| 32 |
15755837 | Common dihydrofolate reductase 19-base pair deletion allele: a novel risk factor for preterm delivery. | 2005 Mar |
2 |
| 33 |
14978269 | Single-molecule and transient kinetics investigation of the interaction of dihydrofolate reductase with NADPH and dihydrofolate. | 2004 Mar 2 |
1 |
| 34 |
12732354 | Further studies on the interaction of nonpolyglutamatable aminopterin analogs with dihydrofolate reductase and the reduced folate carrier as determinants of in vitro antitumor activity. | 2003 May 1 |
1 |
| 35 |
11931624 | Synthesis and in vitro antitumor activity of new deaza analogues of the nonpolyglutamatable antifolate N(alpha)-(4-amino-4-deoxypteroyl)-N(delta)-hemiphthaloyl-L-ornithine (PT523). | 2002 Apr 11 |
1 |
| 36 |
11560482 | Role of S65, Q67, I68, and Y69 residues in homotetrameric R67 dihydrofolate reductase. | 2001 Sep 25 |
1 |
| 37 |
11989624 | One site fits both: a model for the ternary complex of folate + NADPH in R67 dihydrofolate reductase, a D2 symmetric enzyme. | 2001 Nov |
2 |
| 38 |
10683342 | Dihydrofolate reductase from Kaposi's sarcoma-associated herpesvirus. | 2000 Mar 1 |
1 |
| 39 |
10415082 | Assay of dihydrofolate reductase activity by monitoring tetrahydrofolate using high-performance liquid chromatography with electrochemical detection. | 1999 Aug 1 |
1 |
| 40 |
10584062 | Enzyme polarization of substrates of dihydrofolate reductase by different theoretical methods. | 1999 Nov 1 |
1 |
| 41 |
8999931 | Mechanistic studies of R67 dihydrofolate reductase. Effects of pH and an H62C mutation. | 1997 Jan 24 |
1 |
| 42 |
9543003 | A glutamine 67--> histidine mutation in homotetrameric R67 dihydrofolate reductase results in four mutations per single active site pore and causes substantial substrate and cofactor inhibition. | 1997 Dec |
1 |
| 43 |
8845002 | Electrostatic channeling in the bifunctional enzyme dihydrofolate reductase-thymidylate synthase. | 1996 Sep 27 |
2 |
| 44 |
8978793 | [Methotrexate in gynecologic oncology]. | 1996 Dec |
1 |
| 45 |
8852336 | Molecular mechanisms of resistance to antifolates, a review. | 1995 |
2 |
| 46 |
8226776 | Artificial duplication of the R67 dihydrofolate reductase gene to create protein asymmetry. Effects on protein activity and folding. | 1993 Oct 25 |
1 |
| 47 |
8490020 | Specific binding of human dihydrofolate reductase protein to dihydrofolate reductase messenger RNA in vitro. | 1993 May 11 |
2 |
| 48 |
1314649 | Effect of enzyme and ligand protonation on the binding of folates to recombinant human dihydrofolate reductase: implications for the evolution of eukaryotic enzyme efficiency. | 1992 Apr 14 |
1 |
| 49 |
1637816 | Human dihydrofolate reductase: reduction of alternative substrates, pH effects, and inhibition by deazafolates. | 1992 Jul 28 |
1 |
| 50 |
1904273 | Synthesis and biological evaluation of a fluorescent analogue of folic acid. | 1991 Jun 11 |
1 |