Title : Effect of enzyme and ligand protonation on the binding of folates to recombinant human dihydrofolate reductase: implications for the evolution of eukaryotic enzyme efficiency.

Pub. Date : 1992 Apr 14

PMID : 1314649






1 Functional Relationships(s)
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Sentence
Compound Name
Protein Name
Organism
1 koff for dissociation of folate, dihydrofolate (H2folate), and H4folate from their binary complexes with hDHFR is similarly pH dependent. dihydrofolate dihydrofolate reductase Homo sapiens