Title : Molecular mechanisms of resistance to antifolates, a review.

Pub. Date : 1995

PMID : 8852336






2 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 The primary target of MTX is the enzyme dihydrofolate reductase (DHFR) which catalyzes the reduction of folate and 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate. dihydrofolate dihydrofolate reductase Homo sapiens
2 The primary target of MTX is the enzyme dihydrofolate reductase (DHFR) which catalyzes the reduction of folate and 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate. dihydrofolate dihydrofolate reductase Homo sapiens