Title : Mechanistic studies of R67 dihydrofolate reductase. Effects of pH and an H62C mutation.

Pub. Date : 1997 Jan 24

PMID : 8999931






1 Functional Relationships(s)
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1 These results indicate protonated dihydrofolate (pKa = 2.59) is the productive substrate and that R67 DHFR does not possess a proton donor. dihydrofolate dihydrofolate reductase Homo sapiens