| 51 |
11557049 | FKBP12 associates tightly with the skeletal muscle type 1 ryanodine receptor, but not with other intracellular calcium release channels. | 2001 Sep 7 |
2 |
| 52 |
11673895 | An FKBP12 binding assay based upon biotinylated FKBP12. | 2001 Nov 1 |
1 |
| 53 |
10931176 | Sequence diversification of the FK506-binding proteins in several different genomes. | 2000 Aug |
1 |
| 54 |
10416209 | FK506 nephrotoxicity. | 1999 May-Jul |
1 |
| 55 |
10465413 | A proposed molecular model for the interaction of calcineurin with the cyclosporin A-cyclophilin A complex. | 1999 Jul |
4 |
| 56 |
10508685 | Display cloning: functional identification of natural product receptors using cDNA-phage display. | 1999 Oct |
1 |
| 57 |
9697196 | Molecular anchors with large stability gaps ensure linear binding free energy relationships for hydrophobic substituents. | 1998 |
2 |
| 58 |
9727000 | Two-site interaction of nuclear factor of activated T cells with activated calcineurin. | 1998 Sep 11 |
1 |
| 59 |
9154824 | Rapamycin destabilizes interleukin-3 mRNA in autocrine tumor cells by a mechanism requiring an intact 3' untranslated region. | 1997 Jun |
1 |
| 60 |
9223178 | Mean field analysis of FKBP12 complexes with FK506 and rapamycin: implications for a role of crystallographic water molecules in molecular recognition and specificity. | 1997 Jul |
7 |
| 61 |
9396011 | Neural roles of immunophilins and their ligands. | 1997 Oct |
1 |
| 62 |
8626235 | Antascomicins A, B, C, D and E. Novel FKBP12 binding compounds from a Micromonospora strain. | 1996 Mar |
1 |
| 63 |
8627611 | Structure-based design of novel, urea-containing FKBP12 inhibitors. | 1996 Apr 26 |
2 |
| 64 |
8702959 | Characterization of the interaction of FKBP12 with the transforming growth factor-beta type I receptor in vivo. | 1996 Sep 6 |
1 |
| 65 |
8785272 | Tryptophan dynamics of the FK506 binding protein: time-resolved fluorescence and simulations. | 1996 Mar |
2 |
| 66 |
8798476 | FKBP-12 recognition is dispensable for signal generation by type I transforming growth factor-beta receptors. | 1996 Sep 20 |
1 |
| 67 |
8880916 | Dynamic NMR studies of ligand-receptor interactions: design and analysis of a rapidly exchanging complex of FKBP-12/FK506 with a 24 kDa calcineurin fragment. | 1996 Sep |
7 |
| 68 |
8955134 | FAP48, a new protein that forms specific complexes with both immunophilins FKBP59 and FKBP12. Prevention by the immunosuppressant drugs FK506 and rapamycin. | 1996 Dec 20 |
2 |
| 69 |
8994885 | Protein-drug complexes important for immunoregulation and organ transplantation. | 1996 Dec |
1 |
| 70 |
9005438 | FK506-binding protein mutational analysis: defining the active-site residue contributions to catalysis and the stability of ligand complexes. | 1996 Feb |
3 |
| 71 |
21136324 | Practical applications of time-averaged restrained molecular dynamics to ligand-receptor systems: FK506 bound to the Q50R,A95H,K98I triple mutant of FKBP-13. | 1996 Jul |
1 |
| 72 |
21232286 | Expression and regulation of ryanodine receptor/calcium release channels. | 1996 May |
1 |
| 73 |
7529414 | The chemistry of signal transduction. | 1995 Jan 3 |
3 |
| 74 |
7529995 | Time-dependent inhibition of peptidylprolyl cis-trans-isomerases by FK506 is probably due to cis-trans isomerization of the inhibitor's imide bond. | 1995 Jan 1 |
2 |
| 75 |
7531689 | Characterization of an exchange reaction between soluble FKBP-12 and the FKBP.ryanodine receptor complex. Modulation by FKBP mutants deficient in peptidyl-prolyl isomerase activity. | 1995 Feb 10 |
3 |
| 76 |
7533090 | FK506 binding protein 12 mediates sensitivity to both FK506 and rapamycin in murine mast cells. | 1995 Feb |
4 |
| 77 |
7537219 | Schistosoma mansoni: characterization of p50, an immunophilin. | 1995 May |
1 |
| 78 |
7538591 | Determination of the differential effects of hydrogen bonding and water release on the binding of FK506 to native and Tyr82-->Phe82 FKBP-12 proteins using free energy simulations. | 1995 May 5 |
2 |
| 79 |
7541044 | Interaction of FKBP12-FK506 with calcineurin A at the B subunit-binding domain. | 1995 Jun 30 |
3 |
| 80 |
7543369 | X-ray structure of calcineurin inhibited by the immunophilin-immunosuppressant FKBP12-FK506 complex. | 1995 Aug 11 |
6 |
| 81 |
7642551 | FK506 binding protein mutational analysis. Defining the surface residue contributions to stability of the calcineurin co-complex. | 1995 Aug 11 |
7 |
| 82 |
8521476 | Calcineurin associated with the inositol 1,4,5-trisphosphate receptor-FKBP12 complex modulates Ca2+ flux. | 1995 Nov 3 |
4 |
| 83 |
8524402 | Crystal structures of human calcineurin and the human FKBP12-FK506-calcineurin complex. | 1995 Dec 7 |
5 |
| 84 |
8545894 | Inhibitory effect of plasma FKBP12 on immunosuppressive activity of FK506. | 1995 Dec 27 |
5 |
| 85 |
8563622 | Structure comparison of native and mutant human recombinant FKBP12 complexes with the immunosuppressant drug FK506 (tacrolimus). | 1995 Nov |
4 |
| 86 |
15299838 | Comparative X-ray structures of the major binding protein for the immunosuppressant FK506 (tacrolimus) in unliganded form and in complex with FK506 and rapamycin. | 1995 Jul 1 |
4 |
| 87 |
15299839 | Design, synthesis and structure of non-macrocyclic inhibitors of FKBP12, the major binding protein for the immunosuppressant FK506. | 1995 Jul 1 |
8 |
| 88 |
7520438 | Inhibition of calcineurin by a novel FK-506-binding protein. | 1994 Aug 19 |
1 |
| 89 |
7522303 | Immunophilins mediate the neuroprotective effects of FK506 in focal cerebral ischaemia. | 1994 Sep 22 |
2 |
| 90 |
7524662 | Solution structure of FK506 bound to the R42K, H87V double mutant of FKBP-12. | 1994 Nov 22 |
5 |
| 91 |
7529175 | Immunophilins interact with calcineurin in the absence of exogenous immunosuppressive ligands. | 1994 Dec 15 |
3 |
| 92 |
7529739 | Three distinct messenger RNAs can encode the human immunosuppressant-binding protein FKBP12. | 1994 Dec 15 |
2 |
| 93 |
7687744 | Identification of the immunophilins capable of mediating inhibition of signal transduction by cyclosporin A and FK506: roles of calcineurin binding and cellular location. | 1993 Aug |
1 |
| 94 |
1375171 | Solution structure of FK506 bound to FKBP-12. | 1992 May 4 |
2 |
| 95 |
1375751 | Heat capacity changes and hydrophobic interactions in the binding of FK506 and rapamycin to the FK506 binding protein. | 1992 Jun 1 |
3 |
| 96 |
1375932 | Molecular cloning of a 25-kDa high affinity rapamycin binding protein, FKBP25. | 1992 Jun 5 |
2 |
| 97 |
1383226 | Characterization of high molecular weight FK-506 binding activities reveals a novel FK-506-binding protein as well as a protein complex. | 1992 Oct 25 |
6 |
| 98 |
1716149 | Exon organization of the human FKBP-12 gene: correlation with structural and functional protein domains. | 1991 Sep 3 |
1 |