Title : Time-dependent inhibition of peptidylprolyl cis-trans-isomerases by FK506 is probably due to cis-trans isomerization of the inhibitor's imide bond.

Pub. Date : 1995 Jan 1

PMID : 7529995






2 Functional Relationships(s)
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1 For FK506, the kinetics of inhibition of human 12 kDa cytosolic FKBP (FKBP12cy) were clearly dependent on time. Tacrolimus FKBP prolyl isomerase 1A pseudogene 4 Homo sapiens
2 On the other hand, the kinetics and amplitudes of the inhibition of FKBP12cy varied significantly if rapamycin was used as an inhibitor instead of FK 506. Tacrolimus FKBP prolyl isomerase 1A pseudogene 4 Homo sapiens